نبذة مختصرة : Background and objectives Pulsed Electric Field (PEF) ablation has been proposed as a non-thermal energy to treat atrial fibrillation (AF) by ablation of ganglionated plexi using the epicardial approach. The electric field distribution at the target site (heart) and its surroundings has not yet been assessed previously, using epicardial ablation technique. Our objective was to develop computational models, incorporating the real anatomy of the heart and the patient's torso, to assess the electric field distribution when applying epicardial monopolar PEF. Methods A novel 3D realistic full torso model was built with the multi-electrode ablation device placed on the epicardium and a dispersive pad on the patient's back to evaluate the electric field distribution. The 400Â V/cm isoline was used to estimate the â PEF-zoneâ . A 3D limited-domain model was also built including only the region of interest around the ablation device to assess its validity in comparison with the full torso model. Results The electrical field is mainly limited to the target site (PEF-zone with lengths of 25.79 to 29.00Â mm, depths of 5.98â 7.02Â mm and maximum widths of 8.75â 10.57Â mm) and is practically negligible in adjacent organs ( ; This research was funded by Government of Ireland, Disruptive Technology Innovation Fund (DTIF), grant number DT20180123. ; peer-reviewed
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