Mikrowellenablation von kolorektalen Metastasen, Outcome und Prognosefaktoren : eine retrospektive Studie

Purpose: The aim of this study was to evaluate the survival rates (SR), overall survival time (OST), local progression-free survival (PFS) and prognostic factors of patients with colorectal cancer liver metastases (CRLM) undergoing microwave ablation (MWA). Method: We retrospectively enrolled 132 patients who had been treated between 2010 and 2018. For the evaluation of the SR and the OST, all patients were divided according to their indications (curative and palliative). In total, 257 ablations were evaluated for prognostic factors (number of liver metastases, primary tumor origin (PTO), diameter, volume of lesions, duration and energy of ablation. Results: On a total of 132 patients 57 patients underwent a curative procedure and 75 patients received a palliative treatment. Median overall survival was 32.1 months with 93.2% of patients reaching a median recurrence-free survival of 28.3 months. The 1- year and 3- year overall survival rates were 82.72% and 41.66% respectively. On a cohort-based analysis, the median survival and recurrence-free survival of the curative group were higher than the palliative group. The difference in survival and recurrence free survival between both groups was statistically significant (p <0.001). Statistically significant prognostic factors included the location of the primary tumor (p<0.038) and the number of lesions (all p < 0.017). Lesion diameter and volume and ablation duration and energy had no significant correlation with survival (p > 0.05). Conclusions: MWA of CRLM showed better overall survival and progression free survival in patients treated with curative compared to palliative intention. Prognostic factors influencing the survival of patients include the number of lesions and the location of the primary tumor. The lesion’s size and the duration and energy used for ablation were not of significant prognostic value. ; Das kolorektale Karzinom stellt die zweithäufigste Krebstodesursache bei Männern und Frauen in der Bundesrepublik Deutschland dar Das CRC hat ...