The Effects of Remimazolam Tosylate on Postoperative Memory Function in Young and Middle-Aged Patients Undergoing Laparoscopic Surgery

Jingya Liu,1 Mengyu Li,1 Kai Zhao,1 Huimin Wang,1,2 Ping Wu,1,3 Tianyue Yin,1 Keqiang He,1 Xinlu Yang,1 Sheng Wang1 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 2Graduate Department, Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 3Department of Anesthesiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Sheng Wang, Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China, Tel +86 191 5600 7726, Email iamsheng2020@ustc.edu.cn Xinlu Yang, Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China, Tel +86 139 6670 0588, Email xinluyang@ustc.edu.cnPurpose: This randomized controlled trial compared the effects of remimazolam tosylate versus propofol on postoperative memory function in young and middle-aged adults undergoing laparoscopic surgery.Patients and Methods: 228 patients were randomized to receive either remimazolam or propofol (n=114 each) for induction and maintenance of general anesthesia, guided by Bispectral Index (BIS). Memory and cognitive functions were assessed preoperatively and on postoperative days 1 and 3 using the Three-Word Recall Test (TRT), Memory and Executive Screening (MES), and Montreal Cognitive Assessment (MoCA), with a follow-up at one month via the Telephone Interview for Cognitive Status-modified (TICS-m). Serum levels of IL-6, S100β, and NfL were measured preoperatively, at 30 minutes, and 24 hours post-surgery. Perioperative parameters and adverse events were recorded.Results: The incidence of early postoperative memory decline on days 1 and 3 was ...