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Association of Multiple Metabolic and Cardiovascular Markers With the Risk of Cognitive Decline and Mortality in Adults With Alzheimer’s Disease and Ad-Related Dementia or Cognitive Decline: A Prospective Cohort Study

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  • معلومة اضافية
    • بيانات النشر:
      Jefferson Digital Commons
    • الموضوع:
      2024
    • Collection:
      Jefferson Digital Commons (Thomas Jefferson University, Philadelphia)
    • نبذة مختصرة :
      BACKGROUND AND OBJECTIVES: There is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer's disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD. METHODS: We analyzed a cohort of 6,440 participants aged 45-84 years at baseline. Multiple metabolic and cardiovascular disorder factors included the five components of the metabolic syndrome [waist circumference, high blood pressure (HBP), elevated glucose and triglyceride (TG) concentrations, and reduced high-density lipoprotein cholesterol (HDL-C) concentrations], C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), factor VIII, D-dimer, and homocysteine concentrations, carotid intimal-medial thickness (CIMT), and urine albumin-to-creatinine ratio (ACR). Cognitive decline was defined using the Cognitive Abilities Screening Instrument (CASI) score, and AD/ADRD cases were classified using clinical diagnoses. RESULTS: Over an average follow-up period of 13 years, HBP and elevated glucose, CRP, homocysteine, IL-6, and ACR concentrations were significantly associated with the risk of mortality in the individuals with incident AD/ADRD or cognitive decline. Elevated D-dimer and homocysteine concentrations, as well as elevated ACR were significantly associated with incident AD/ADRD. Elevated homocysteine and ACR were significantly associated with cognitive decline. A dose-response association was observed, indicating that an increased number of exposures to multiple risk factors corresponded to a higher risk of mortality in individuals with cognitive decline or with AD/ADRD. CONCLUSION: Findings from our study reaffirm the significance of preventable and controllable factors, including HBP, hyperglycemia, elevated CRP, D-dimer, and homocysteine concentrations, as well as, ACR, as potential risk factors for cognitive decline and ...
    • File Description:
      application/pdf
    • Relation:
      https://jdc.jefferson.edu/cardiologyfp/148; https://jdc.jefferson.edu/context/cardiologyfp/article/1149/viewcontent/Association_of_multiple_metabolic_and_cardiovascular_markers.pdf; https://jdc.jefferson.edu/context/cardiologyfp/article/1149/filename/0/type/additional/viewcontent/Supplementary_Table.pdf
    • الدخول الالكتروني :
      https://jdc.jefferson.edu/cardiologyfp/148
      https://jdc.jefferson.edu/context/cardiologyfp/article/1149/viewcontent/Association_of_multiple_metabolic_and_cardiovascular_markers.pdf
      https://jdc.jefferson.edu/context/cardiologyfp/article/1149/filename/0/type/additional/viewcontent/Supplementary_Table.pdf
    • Rights:
      http://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.8C15658A