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Aqueous humor polymerase chain reaction in uveitis - utility and safety

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  • معلومة اضافية
    • بيانات النشر:
      BioMed Central
    • الموضوع:
      2016
    • Collection:
      Imperial College London: Spiral
    • نبذة مختصرة :
      Background: To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. Methods: Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC paracentesis with PCR were reviewed. The main outcome measure was frequency of PCR positivity. Secondary outcomes were alteration of treatment, safety of paracentesis, and correlation of keratitic precipitates with PCR positivity, Results: The overall PCR positivity was 48.9 % (22/45). Therapy was changed because of the PCR results in 14/45 patients (37.7 %). One patient experienced a paracentesis related complication (1/45, 2.2 %) without long-term sequelae. Conclusion: Aqueous PCR altered the diagnosis and treatment in over a third of our patients and was relatively safe. Aqueous PCR should be considered for uveitis of atypical clinical appearance, recurrent severe uveitis of uncertain etiology, and therapy refractory cases.
    • Relation:
      BMC Ophthalmology; http://hdl.handle.net/10044/1/53497
    • الرقم المعرف:
      10.1186/s12886-016-0369-z
    • الدخول الالكتروني :
      http://hdl.handle.net/10044/1/53497
      https://doi.org/10.1186/s12886-016-0369-z
    • Rights:
      © The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    • الرقم المعرف:
      edsbas.8B6AE0DE