Dopplervelocimetria da artéria oftálmica em mulheres na perimenopausa e pós-menopausa usuárias de terapia hormonal ; Colour Doppler analisys of the ophthalmic artery in perimenopause and postmenopausal women using hormone replacement therapy

Background: The vascular endothelium has specific estrogen receptors and the impact of hormone therapy (HT) on circulation is associated with cardiovascular protection in perimenopause and postmenopause. Blood vessels can be assessed by ultrasound Doppler velocimetry, and more specifically, the study of the ophthalmic artery can be used for brain vessel assessment, and more recently, a possible method for cardiovascular risk assessment. Methods: We performed a cross-sectional study with peri and postmenopausal women; divided into three groups: 60 non-HT users (control group), 23 estrogen therapy users (ET group) and 23 estrogen-progesterone therapy users (EPT group). Doppler velocimetry of the ophthalmic artery (OA) was performed with the evaluation of: resistance index (RI), pulsatility index (PI), peak systolic velocity (P1), second peak systolic velocity (P2), peaks velocities ratio (PVR), end-diastolic velocity (EDV) and ratio of systolic and diastolic velocity means (RSD). Results: There was no significant difference between the groups in Doppler velocimetry indices of OA. We observed a positive correlation of RSD with age only in the control group (r = 0.34, p = 0.01). Conclusions: There is a positive correlation between RSD and age in the control group. Therefore, this new index is a promising instrument in the noninvasive assessment of cardiovascular risk. ; Dissertação (Mestrado) ; Background: O endotélio vascular possui locais específicos de ligação aos estrogênios e o impacto da terapia hormonal (TH) na circulação associa-se à proteção cardiovascular na perimenopausa e pós-menopausa. Os vasos sanguíneos podem ser avaliados por meio da dopplervelocimetria, e, mais especificamente, o estudo da artéria oftálmica pode ser utilizado para avaliação de vasos cerebrais, e, mais recentemente, possível método de avaliação do risco cardiovascular. Métodos: Estudo transversal com mulheres na perimenopausa e pós-menopausa; divididas em três grupos: 60 não usuárias de TH (grupo controle), 23 usuárias de terapia ...