Evaluation of the Relationship of MPV, RDW and PVI Parameters with Disease Severity in Covid-19 Patients ; Procjena odnosa srednjeg volumena trombocita, širine distribucije eritrocita i indeksa volumena trombocita s težinom bolesti kod bolesnika s COVID-19

Coronavirus was first detected in three severe pneumonia cases in Wuhan, China, in December 2019. Studies on red cell distribution width (RDW-CV) and mean platelet volume (MPV) laboratory parameters, which can be examined in complete blood count in COVID-19 patients, are still very limited. However, to the best of our knowledge, there are no studies examining the relationship between platelet volume index (PVI) and disease severity in COVID-19 patients, which was evaluated in this study. The aim of this study was to evaluate the relationship of disease severity in COVID-19 patients with their MPV, RDW, and PVI parameters. The study included 92 COVID-19 patients as a study group and 84 healthy individuals as control group. All laboratory data and radiological images were scanned retrospectively from patient files and hospital information system. Evaluation of the RDW-CV and MPV blood parameters, and PVI measured in COVID-19 patients yielded statistically significant differences according to the disease severity. We suggest that RDW-CV and PVI, evaluated within the scope of the study, may be the parameters that should be considered in the early diagnosis of the disease, from the initial stages of COVID-19. In addition, we think that the RDW-CV and MPV laboratory parameters, as well as PVI, which all are simple, inexpensive and widely used hematologic tests, can be used as important biomarkers in determining COVID-19 severity and mortality. ; Koronavirus je prvi put otkriven kod tri slučaja teške upale pluća u Wuhanu, Kina u prosincu 2019. godine. Istraživanja laboratorijskih parametara širine distribucije eritrocita (RDW-CV) i srednjeg volumena trombocita (MPV) koji se mogu testirati unutar kompletne krvne slike kod bolesnika s COVID-19 još uvijek su vrlo ograničena. Međutim, prema našim saznanjima, nema istraživanja koja bi se bavila odnosom indeksa volumena trombocita (PVI) i težine bolesti kod ovih bolesnika, a upravo to smo ispitivali u našem istraživanju. Cilj studije bio je procijeniti odnos težine bolesti u ...