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Gene and protein expression of a soluble form of CTLA-4 in a healthy dog

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Japanese Society of Veterinary Science
    • الموضوع:
      2017
    • Collection:
      Obihiro University: Obihiro Archives of Knowledge (OAK) / 帯広畜産大学学術情報リポジトリ
    • الموضوع:
      649
    • نبذة مختصرة :
      application/pdf ; Cytotoxic T lymphocyte associated gene-4 (CTLA-4) is a costimulatory molecule, expressed on the surface of activated T cells that negatively regulates T cell activation. In humans, alternative splicing of the CTLA-4 gene generates two major isoforms of mRNA, and a soluble form of CTLA-4 (sCTLA-4) was detected in normal human serum. We describe alternatively spliced mRNA expressed in peripheral blood mononuclear cells obtained from a healthy dog lacking the transmembrane domain coded by exon 3 of the CTLA-4 gene. Immunoprecipitation and western blotting of dog serum revealed a band of approximately 23-kDa, which is consistent with the predicted size, based on the amino acid sequence of the canine sCTLA-4 obtained in this study. ; journal article
    • File Description:
      application/pdf
    • ISSN:
      09167250
    • Relation:
      Journal of Veterinary Medical Science; 79; 871; 875; AA10796138; https://obihiro.repo.nii.ac.jp/records/1280
    • الدخول الالكتروني :
      https://obihiro.repo.nii.ac.jp/record/1280/files/79_16-0583.pdf
      https://obihiro.repo.nii.ac.jp/records/1280
    • Rights:
      This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-ncnd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
    • الرقم المعرف:
      edsbas.7A456B38