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Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients. ; Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients.: Sickle cell disease and cerebral oxygenation

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  • معلومة اضافية
    • Contributors:
      Adaptations au Climat Tropical, Exercice et Santé (ACTES); Université des Antilles et de la Guyane (UAG); Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB); Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)); Institut National de la Transfusion Sanguine Paris (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Institut National de la Transfusion Sanguine Paris (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA); Réponses Cellulaires et Fonctionnelles à l'Hypoxie (LRPH); Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-UFR SMBH; Unité Transversale de la Drépanocytose; CHU Pointe-à-Pitre / Abymes Guadeloupe; Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane); Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -CHU de la Martinique Fort de France -Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française; Service d'Orthopédie et de Traumatologie; Université des Antilles et de la Guyane (UAG)-CHU Pointe-à-Pitre / Abymes Guadeloupe; This work was supported by local grants from the Academic Hospital of Pointe-à-Pitre (PHRC CHU de Pointe à Pitre). PhD funding of X.W. was supported by the association "Ensemble contre la drépanocytose" and by the regional council of Guadeloupe
    • بيانات النشر:
      HAL CCSD
      Wiley
    • الموضوع:
      2012
    • نبذة مختصرة :
      International audience ; Sickle cell anemia (SS) is characterized by a reduced cerebral microvascular oxygen saturation (cerebral TOI), which is not associated with hemoglobin concentration. Cerebral TOI has never been studied in sickle cell-hemoglobin C disease (SC). We focused on the relationships between hemorheological alterations and cerebral TOI in sickle cell patients with no cerebral vasculopathy and on the usefulness of TOI variability to assess the cerebral vasomotion activity. The blood rheological profile, the level of cerebral TOI (spatial resolved spectroscopy) and the cerebral TOI variability, which reflects vasomotion activity, were compared between 20 healthy subjects (AA), 21 SC patients, and 21 SS patients. Cerebral TOI exhibited the following order: AA > SC > SS. The low cerebral TOI in SS patients was related to red blood cell aggregation and deformability properties. The cerebral TOI variability of SS and SC patients was increased above healthy values and vasomotion activity was negatively associated with the reduced cerebral TOI in SS patients. We demonstrated that (1) blood rheology could be involved in the reduced cerebral TOI in SS patients but not in SC patients; (2) vasomotion activity is increased in SS and SC patients to compensate for the reduced cerebral TOI.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/22911571; inserm-00838966; https://inserm.hal.science/inserm-00838966; https://inserm.hal.science/inserm-00838966/document; https://inserm.hal.science/inserm-00838966/file/2013_Waltz_American_Journal_of_Hematology.pdf; PUBMED: 22911571
    • الرقم المعرف:
      10.1002/ajh.23318
    • الدخول الالكتروني :
      https://inserm.hal.science/inserm-00838966
      https://inserm.hal.science/inserm-00838966/document
      https://inserm.hal.science/inserm-00838966/file/2013_Waltz_American_Journal_of_Hematology.pdf
      https://doi.org/10.1002/ajh.23318
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.76FA06F7