Contributors: Bonifazi, M.; Mei, F.; Skrami, E.; Latini, L. L.; Amico, D.; Balestro, E.; Bini, F.; Bonifazi, F.; Caminati, A.; Candoli, P.; Cinti, S.; Contucci, S.; Berardino, A. D. M.; Harari, S.; Levi, G.; Lococo, S.; Menditto, V.; Marchetti, G.; Piciucchi, S.; Poletti, V.; Ravaglia, C.; Saetta, M.; Svegliati-Baroni, G.; Tomassetti, S.; Tamburrini, M.; Zanforlin, A.; Zuccon, U.; Zuccatosta, L.; Gasparini, S.; Carle, F.
نبذة مختصرة : Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
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