نبذة مختصرة : Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability. Male rats (n = 24) were randomly assigned to control, CCI, CCI + curcumin (60 mg/kg), and CCI + CLNs (40 mg/kg) groups. CCI was induced through sciatic nerve ligation, followed by 14 days of treatment. Behavioral assessments included thermal and mechanical pain sensitivity, anxiety-like behavior (elevated plus maze), and sciatic nerve function (SFI). Serum inflammatory (TNF-α, IL-6) and oxidative stress markers (MDA, TAC, SOD, GSH) were measured, alongside histological analysis. Compared to curcumin, CLNs showed superior efficacy in improving pain thresholds, anxiety-like behaviors, and SFI scores. CLNs significantly lowered TNF-α and IL-6 levels and enhanced SOD activity, with no intergroup differences in MDA, TAC, or GSH. Histology confirmed nerve regeneration and reduced neurodegeneration. CLNs effectively alleviated neuropathic pain, reduced neuroinflammation, and improved functional recovery after sciatic nerve injury, while mitigating anxiety-like behaviors.
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