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Genetics of Severe Obesity

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Current Medicine Group
    • الموضوع:
      2018
    • Collection:
      St George's University of London: Repository
    • نبذة مختصرة :
      Purpose of Review This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R. Recent Findings There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity. Summary The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population. Keywords Obesity Leptin Melanocortin-4 receptor GWAS BMI
    • File Description:
      application/pdf
    • ISSN:
      1539-0829
    • Relation:
      https://openaccess.sgul.ac.uk/id/eprint/110066/1/Fairbrother_et_al-2018-Current_Diabetes_Reports%202018.pdf; Fairbrother, U; Kidd, E; Malagamuwa, T; Walley, AJ (2018) Genetics of Severe Obesity. Current Diabetes Reports, 18. p. 85. ISSN 1539-0829 https://doi.org/10.1007/s11892-018-1053-x SGUL Authors: Walley, Andrew John
    • الدخول الالكتروني :
      https://openaccess.sgul.ac.uk/id/eprint/110066/
    • Rights:
      cc_by_4
    • الرقم المعرف:
      edsbas.621D2BD0