Formulation and Evaluation of Transdermal Patch of Cissus Quadrangularis L for the Management of Arthritis

Six batches of (HPE1, HPE2, HPE3&HPF1, HPF2, HPF3) Ethanolic Extract Transdermal patches were prepared by solvent casting technique. The various formulation parameters, Drug-Polymer ratios and permeation enhancers were optimized to get thin, transparent, smooth, stable and high permeable transdermal patches. HPTLC finger printing of Cissus quadrangularis L showed that presence of flavonoids, alkaloids and glycosides. The FTIR graphs of active constituents, excipients and formulations showed that there is no extra peak (or) broadening of peaks were observed and thus it indicates that there is no incompatibility between drug and excipients. From the optimization, best 2 formulations HPE1& HPF2 were selected based on physicochemical evaluation and in vitro diffusion study 0.3ml of glycerin was added as plasticizer to produce a flexible patch without having major influence on their diffusion property. If the amount exceeds, the film loses its flexibility and become stiff. The plasticizer diffuses through the patch and softens the polymer particles. This softening promotes latex coalescence and patch formation. All the six batches were evaluated for Percentage Moisture uptake, Percentage Moisture content, Thickness, Folding Endurance, Percentage Drug content, Percent Elongation, Tensile strength. The formulations HPE1 & HPE2 showed maximum % Moisture uptake, Moisture content, Thickness, folding endurance, % Drug content, Percent elongation, Tensile strength No significant difference in drug content was observed between the patches among the six formulations. This indicates the homogenous dispensing of drug during the patch preparation. The data obtained from in vitro diffusion profile of selected formulations were fitted with various kinetic equations to determine the mechanism of drug diffusion and diffusion rate as indicated by higher correlation coefficients (r2). The drug diffusion from HPE1 & HPF1 follows zero order and non-fickian diffusion. These findings indicates that the drug diffusion from ...