Association Between Lactate Dehydrogenase/Albumin Ratio and in-Hospital Mortality in Patients with Acute Aortic Dissection

Saimire Mutailifu,* Qing Zhu,* Menghui Wang, Delian Zhang, Shuaiwei Song, Nanfang Li Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region; Hypertension Research Laboratory; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang, 830001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nanfang Li, Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region; Hypertension Research Laboratory; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, No. 91 TianChi Road, Urumqi, Xinjiang, 830001, People’s Republic of China, Tel +86-13999179937, Fax +86-09918564816, Email lnanfang2016@sina.comBackground: Previous studies have identified the lactate dehydrogenase/albumin ratio (LAR) as an independent prognostic marker, significantly predicting in-hospital mortality in patients with inflammation and cancer. Building on this, the current study is designed to explore the association between LAR and mortality during hospitalization in patients with acute aortic dissection (AAD).Methods: This retrospective study included patients diagnosed with AAD between January 1, 2010, and March 1, 2023. Patients were categorized into three groups based on LAR tertiles: T1 (< 5.01), T2 (5.01– 6.43), and T3 (> 6.43). Multivariable logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). In addition, subgroup analysis, receiver operating characteristic (ROC) curves, decision curve analysis (DCA), clinical impact curve analysis, Boruta algorithm, and the Kaplan-Meier analysis were applied to ...