Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre®) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called ‘resistant’). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p<0.05) in long-term use, and macrolides (p<0.05) and tetracyclines (p<0.01) in short-term use. ; Penggunaan antimikroba di peternakan mengakselerasi proses resistansi antimikroba pada sektor peternakan dan berpotensi mengancam kesehatan manusia. Studi ini bertujuan untuk mengetahui hubungan penggunaan antimikroba dengan kejadian ...