Pregnancy complications inHIV‐positive women: 11‐year data from theFrankfurtHIV Cohort

ObjectivesThe aim of the study was to assess pregnancy complications inHIV‐positive women and changes in the rates of such complications over 11 years in theFrankfurtHIV Cohort.MethodsThere were 330 pregnancies inHIV‐positive women between 1January 2002 and 31December 2012. The rate of pregnancy‐related complications, such as gestational diabetes mellitus (GDM), pre‐eclampsia and preterm delivery, the mode of delivery and obstetric history were analysed. Maternal and neonatal morbidity/mortality as well asHIVmother‐to‐child transmission (MTCT) were evaluated.ResultsIn our cohort,GDMwas diagnosed in 38 of 330 women (11.4%). Five women (1.5%) developed pre‐eclamspia or hypertension. In 16 women (4.8%), premature rupture of membranes (PROM) occurred and 46 women (13.7%) were admitted with preterm contractions. The preterm delivery rate was 36.5% (n = 122), and 26.9% of deliveries (n = 90) were between 34+0 and 36+6 weeks of gestation. Over the observation period, the percentage of women with undetectableHIVviral load (VL) increased significantly (P P P GDM, pre‐eclampsia,PROMor preterm contractions.ConclusionsIn the 11 years of our analysis, there was a significant reduction in the rate of preterm deliveries and an increase in the vaginal delivery rate, possibly reflecting changes in treatment policies in the same period and the availability of more effective antiretroviral therapy options. The rates of complications such asGDM, pre‐eclampsia, preterm contractions,PROMand postnatal complications were stable over the 11 years, but were still increased compared with the general population.