The Investigation of Cell Adhesion Molecules in the Lung Tissues of Cattle with Cystic Echinococcosis

Cystic echinococcosis is a zoonotic disease with worldwide distribution caused by Echinococcus granulosus,represents a substantial global health problem. Hydatid cyst (Echinococcus) has a remarkable negative effect on thehealth of people and the economic development of the country. The objective of this study was to investigate the CD68,nicotinamide nucleotide adenylyltransferase 3 (NMNAT 3), Neuregulin 1 (NRG1) and Neuregulin 2 (NRG2) expres-sions in bovine lungs infected with E. granulosus and to identify whether they have any correlation with pulmonarypathology. For this purpose, 30 bovine lung tissues were used between January 2016 and December 2016 collected inKırıkkale slaughterhouse. In histopathologic examinations, proliferation of fibrous connective tissue and infiltrationof mononuclear cells were detected in the lung tissues of the bovine. Most of the cysts were seen to be quite thickcapsule. There was also a cellular line rich in abundant fibroblasts and mononuclear cells. The cyst wall was found tobe an eosinophilic laminar structure. There was infiltration with lymphocytes and macrophages, especially eosinophilsand giant cells. Immunohistochemically, CD68 positivity was seen around the bronchi, bronchioles and cystic matter.However; NMNAT 3, NRG1 and NRG2 showed no positive reactions in macrophages, bronchi, bronchioles and alveo-lar epithelium. These results indicate that NMNAT 3, NRG1 and NRG2 pathways were not used in pulmonary pathol-ogy. Therefore, it is the most important result of the study that the adhesion molecules in pulmonary pathology are notoriginating from NMNAT 3, NRG1 and NRG2.