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Emergence of multi-drug-resistant Mycobacterium tuberculosis in Niger: A snapshot based on whole-genome sequencing

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  • معلومة اضافية
    • Contributors:
      Microbes évolution phylogénie et infections (MEPHI); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS); Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille); Virulence Bactérienne et Infections Chroniques (VBIC); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Laboratoire National de Référence des IST/VIH et de la Tuberculose; ANR-17-CE35-0006,PRIME,PRédire la niche écologique de souches Infectieuses de pathogènes humains comme un facteur déterminant dans l'éMErgence des maladies infectieuses(2017)
    • بيانات النشر:
      Public Library of Science (PLoS), 2022.
    • الموضوع:
      2022
    • نبذة مختصرة :
      Background Among other West African countries experiencing the high endemicity of deadly tuberculosis, the situation in Niger is poorly evidenced by microbiological investigations. Methodology/Principal findings The study of 42 isolates of Mycobacterium tuberculosis from Niger by whole genome sequencing using Illumina iSeq technology yielded four M. tuberculosis lineages: Indo-Oceanic L1 (n = 1) (2.3%), East-Asian (n = 1) (2.3%), East-African Indian L3 (n = 2) (4.7%) and Euro-American L4 (n = 38) (90.4%). The sub-lineage L4.1.3 comprising 18 isolates (47.3%) was predominant, followed by the L4.6.2.2 sub-lineage (Cameroon genotype, n = 13 isolates) (34.2%). Investigating drug resistance profile for 12 antibiotics found 8/42 (19%) pan-susceptible isolates and 34/42 (81%) resistant isolates; with 40/42 (95.2%) isolates being susceptible to clofazimine-bedaquiline. Conclusions/Significance These unprecedented data from Niger highlight the dynamics of tuberculosis transmission and drug resistance in Niger and may assist tuberculosis control in this country which continues to support a high burden of tuberculosis.
    • ISSN:
      1935-2735
    • الرقم المعرف:
      10.1371/journal.pntd.0010443
    • Rights:
      CC BY
      URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    • الرقم المعرف:
      edsair.doi.dedup.....8b7ca5e2db90d1e201bba69cd4e7fac7