Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • بيانات النشر:
      MDPI AG, 2024.
    • الموضوع:
      2024
    • نبذة مختصرة :
      Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor prognosis due to the lack of effective treatment options. Therefore, new treatment options are required. Sphingolipids are essential components of the cell membrane, while complement components are integral to innate immunity, and both play a critical role in regulating glioblastoma survival signaling. This review focuses on recent studies investigating the functional roles of sphingolipid metabolism and complement activation signaling in glioblastoma. It also discusses how targeting these two systems together may emerge as a novel therapeutic approach.
    • ISSN:
      2673-6411
    • الرقم المعرف:
      10.3390/biochem4020007
    • Rights:
      CC BY
      URL: http://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    • الرقم المعرف:
      edsair.doi.dedup.....82b4531f3d865ed3184733f5c50ba3fa