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Genome‐wide meta‐analysis identifies 3 novel loci associated with stroke

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Admin, Oskar; Ludwig-Maximilians-Universität München (LMU); University of Edinburgh; Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); University of Cambridge [UK] (CAM); Apollo - University of Cambridge Repository
    • بيانات النشر:
      Wiley, 2018.
    • الموضوع:
      2018
    • نبذة مختصرة :
      We conducted a European‐only and transancestral genome‐wide association meta‐analysis in 72,147 stroke patients and 823,869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E‐8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04–1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E‐8, OR = 1.04, 95% CI = 1.03–1.06) and near DYRK1A (rs720470; p = 6.1E‐9, OR = 1.05, 95% CI = 1.03–1.07) at genome‐wide significance for stroke. Effect sizes of known stroke loci were highly correlated between UKB and MEGASTROKE. Using Mendelian randomization, we further show that genetic variation in the nitric oxide synthase–nitric oxide pathway in part affects stroke risk via variation in blood pressure. Ann Neurol 2018;84:934–939
    • File Description:
      application/pdf
    • ISSN:
      1531-8249
      0364-5134
    • الرقم المعرف:
      10.1002/ana.25369
    • الرقم المعرف:
      10.17863/cam.34752
    • Rights:
      CC BY
      CC BY NC
    • الرقم المعرف:
      edsair.doi.dedup.....7d66a082364a50c224f01dd1892fceb5