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Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions

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  • معلومة اضافية
    • بيانات النشر:
      SAGE Publications, 2024.
    • الموضوع:
      2024
    • نبذة مختصرة :
      In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.
    • ISSN:
      1877-718X
      1877-7171
    • الرقم المعرف:
      10.3233/jpd-240210
    • الرقم المعرف:
      10.34734/fzj-2024-04901
    • Rights:
      CC BY NC
      URL: http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    • الرقم المعرف:
      edsair.doi.dedup.....4ecd091b263d1fa31c746065dbb6ae03