Id4 is required for normal ependymal cell development

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المؤلفون: Brenda Rocamonde; Vicente Herranz-Pérez; Jose Manuel Garcia-Verdugo; Emmanuelle Huillard
المصدر:
Front Neurosci
Repositori Universitat Jaume I
Universitat Jaume I
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Universitat de València
Rocamonde, Brenda Herranz Pérez, Vicente García Verdugo, José Manuel Huillard, Emmanuelle 2021 ID4 is required for normal ependymal cell development Frontiers In Neuroscience 15 668243 1 7
instname
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience, Frontiers, 2021, 15, pp.668243. ⟨10.3389/fnins.2021.668243⟩
الموضوع:
0301 basic medicine; [SDV]Life Sciences [q-bio]; Cèl·lules; brain; Neurosciences. Biological psychiatry. Neuropsychiatry; 03 medical and health sciences; ID4; Neurociències; development; ependymal cell; transcription factor; RC321-571; Neuroscience
نوع التسجيلة:
Article
Other literature type
الدخول الالكتروني :
https://hal.sorbonne-universite.fr/hal-03229800/file/fnins-15-668243.pdf
https://www.frontiersin.org/articles/10.3389/fnins.2021.668243/pdf
https://pubmed.ncbi.nlm.nih.gov/33967685
http://hdl.handle.net/10234/194568
https://doi.org/10.3389/fnins.2021.668243
https://hdl.handle.net/10550/82313
https://hdl.handle.net/10550/82313
https://doi.org/10.3389/fnins.2021.668243
https://doaj.org/article/eaf475b476e841a0a4de3c54eee50a86
https://biorxiv.org/content/10.1101/2021.02.15.431205v1.full.pdf
https://www.biorxiv.org/content/10.1101/2021.02.15.431205v1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100185/
https://pubmed.ncbi.nlm.nih.gov/33967685/
https://www.frontiersin.org/articles/10.3389/fnins.2021.668243/full
https://europepmc.org/article/PPR/PPR283621
https://hal.archives-ouvertes.fr/hal-03229800v1
https://hal.sorbonne-universite.fr/hal-03229800
https://hal.sorbonne-universite.fr/hal-03229800/file/fnins-15-668243.pdf
https://hal.sorbonne-universite.fr/hal-03229800/document

معلومة اضافية
- Contributors:
  Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM); Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); Instituto de Salud Carlos III [Madrid] (ISC); Universitat de València (UV); Universitat Jaume I
- بيانات النشر:
  Cold Spring Harbor Laboratory, 2021.
- الموضوع:
  2021
- نبذة مختصرة :
  Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid flow (CSF) and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator Id4 is involved in ependymal cell development and maturation. We observed thatId4-deficient mice display altered ependymal cytoarchitecture, decreased ependymal cell number, altered CSF flow and enlarged ventricles. Our findings open the way for a potential role of Id4 in ependymal cell development and/or motor cilia function.
- File Description:
  application/pdf
- ISSN:
  1662-453X
- الرقم المعرف:
  10.1101/2021.02.15.431205
- الرقم المعرف:
  10.3389/fnins.2021.668243
- Rights:
  CC BY
  CC BY SA
- الرقم المعرف:
  edsair.doi.dedup.....4b5628c3306f1fbc6b86dd73ebf63e66

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