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A detoxication route for acetaldehyde: metabolism of diacetyl, acetoin, and 2,3-butanediol in liver homogenate and perfused liver of rats.

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  • المؤلفون: Otsuka M;Otsuka M; Mine T; Ohuchi K; Ohmori S
  • المصدر:
    Journal of biochemistry [J Biochem] 1996 Feb; Vol. 119 (2), pp. 246-51.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Print ISSN: 0021-924X (Print) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Abingdon, UK : Oxford University Press
      Original Publication: Tokyo : Japanese Biochemical Society
    • الموضوع:
      Acetaldehyde/*pharmacokinetics ; Acetoin/*metabolism ; Butylene Glycols/*metabolism ; Diacetyl/*metabolism ; Liver/*metabolism; Fatty Alcohols/metabolism ; Animals ; Inactivation, Metabolic ; Perfusion ; Rats
    • نبذة مختصرة :
      The metabolism of diacetyl (2,3-butanedione), acetoin (3-hydroxy-2-butanone), and 2,3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2,3-butanediol in these experiments, but acetoin and 2,3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2,3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2,3-butanediol required NADH. Acetoin and 2,3-butanediol were more readily accumulated than diacetyl in brain tissue.
    • الرقم المعرف:
      0 (Butylene Glycols)
      0 (Fatty Alcohols)
      45427ZB5IJ (2,3-butylene glycol)
      57419-49-5 (acyloin)
      BG4D34CO2H (Acetoin)
      GO1N1ZPR3B (Acetaldehyde)
      K324J5K4HM (Diacetyl)
    • الموضوع:
      Date Created: 19960201 Date Completed: 19970206 Latest Revision: 20190512
    • الموضوع:
      20260130
    • الرقم المعرف:
      10.1093/oxfordjournals.jbchem.a021230
    • الرقم المعرف:
      8882713