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Solubilizing the Insoluble. (cover story)

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  • المؤلفون: Van Arnum, Patricia
  • المصدر:
    Pharmaceutical Technology. Nov2010, Vol. 34 Issue 11, p50-56. 4p.
  • معلومة اضافية
    • الموضوع:
      Drug solubility testing; Drug absorption; Pharmaceutical industry; Solubility; Permeability; Quality control
    • نبذة مختصرة :
      The article reports on the importance of amending the solubility of poorly water-soluble drugs. It states that the solubility of the active pharmaceutical ingredients play a crucial role in drug disposition because the main pathway for drug absorption is a function of permeability and solubility. On the contrary, poor solubility can lead to inadequate exposure in efficacy and toxicity studies. It notes that poor solubility is caused by high hydrophobicity and highly crystalline structures.