Emergence of Novel Fluoroquinolone Resistance Mutations in Mycoplasma bovis, China, 2008-2023.

Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-

Mycoplasma bovis*/genetics ; Mycoplasma bovis*/drug effects ; Mycoplasma bovis*/isolation & purification ; Fluoroquinolones*/pharmacology ; Drug Resistance, Bacterial*/genetics ; Mycoplasma Infections*/veterinary ; Mycoplasma Infections*/microbiology ; Mycoplasma Infections*/epidemiology ; Mycoplasma Infections*/history ; Anti-Bacterial Agents*/pharmacology ; Cattle Diseases*/microbiology ; Cattle Diseases*/epidemiology ; Cattle Diseases*/history ; Mutation*; China/epidemiology ; DNA Topoisomerase IV/genetics ; DNA Gyrase/genetics ; Animals ; Cattle ; Microbial Sensitivity Tests ; Genotype ; History, 21st Century

We investigated quinolone resistance in Mycoplasma bovis samples isolated in China during 2008-2023. Sequence type 52 was the dominant genotype; GyrA (S83F/Y) and ParC (S80R) protein double mutations caused high resistance to fluoroquinolones. Increased vigilance and surveillance of M. bovis infections in cattle will be needed to prevent disease.

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Keywords: China; MLST; Mycoplasma bovis; ST52; antimicrobial resistance; bacteria; fluoroquinolone; fluoroquinolone resistance; genetic evolutionary analysis; multilocus sequence typing; sequence type

0 (Fluoroquinolones)
0 (Anti-Bacterial Agents)
EC 5.99.1.- (DNA Topoisomerase IV)
EC 5.99.1.3 (DNA Gyrase)

Date Created: 20250724 Date Completed: 20250724 Latest Revision: 20250802

20260130

PMC12309742

10.3201/eid3108.241137

40705309