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Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study.

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  • المؤلفون: Jia HY;Jia HY; He PY; He PY; Zhang J; Zhang J; Zhou MJ; Zhou MJ; Xu XM; Xu XM
  • المصدر:
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2025 Dec; Vol. 41 (1), pp. 2528817. Date of Electronic Publication: 2025 Jul 08.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: [Carnforth, Lancashire ; Park Ridge, N.J.] : Parthenon Pub., [c1987-
    • الموضوع:
      Diabetes, Gestational*/blood ; Diabetes, Gestational*/epidemiology ; Pregnancy Trimester, First*/blood ; Cholesterol, HDL*/blood ; Triglycerides*/blood; China/epidemiology ; Humans ; Pregnancy ; Female ; Retrospective Studies ; Adult ; Risk Factors
    • نبذة مختصرة :
      This retrospective cohort study examined the association between first-trimester triglyceride-to-HDL cholesterol (TG/HDL-C) ratio and gestational diabetes mellitus (GDM) risk among 2,356 pregnant women from Shanghai General Hospital between October 2019, and June 2021. Using logistic regression and restricted cubic spline models, we found the TG/HDL-C ratio was an independent GDM predictor (OR:1.37, 95%CI:1.16-1.62, p<0.001), persisting after adjustment (aOR:1.65, 95%CI:1.27-2.13, p<0.001). Nonlinear dose-response relationships were observed (p-interaction<0.05), with stronger associations in women >35 years (OR:1.60, 95%CI:1.12-2.28) and those with BMI≥25kg/m² (OR:1.78, 95%CI:1.25-2.54). First-trimester TG/HDL-C ratio elevation significantly increases GDM risk, suggesting its potential for early risk stratification and targeted prevention.
    • Contributed Indexing:
      Keywords: Gestational diabetes mellitus; TG/HDL-C ratio; metabolic disorder; risk factors; serum lipid profile
    • الرقم المعرف:
      0 (Cholesterol, HDL)
      0 (Triglycerides)
    • الموضوع:
      Date Created: 20250708 Date Completed: 20250708 Latest Revision: 20250708
    • الموضوع:
      20260130
    • الرقم المعرف:
      10.1080/09513590.2025.2528817
    • الرقم المعرف:
      40627617