Concordant and discordant roles of remnant cholesterol and hs-CRP in cardiovascular disease; gender stratified analysis.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2002-

C-Reactive Protein*/metabolism ; Cholesterol*/blood ; Cardiovascular Diseases*/blood ; Cardiovascular Diseases*/epidemiology ; Coronary Artery Disease*/blood; Biomarkers/blood ; Iran/epidemiology ; Ischemic Stroke/blood ; Humans ; Male ; Female ; Middle Aged ; Aged ; Sex Factors ; Risk Factors ; Adult ; Cohort Studies

Introduction: Evidence has found that high-sensitivity C-reactive protein (hs-CRP) can predict cardiovascular disease (CVD). Additionally, some research has suggested a combined effect of hs-CRP and remnant cholesterol (RC) in the development of CVD. Recognizing the significance of assessing both markers as predictive factors, this study aims to examine the association between RC and hs-CRP levels with the occurrence of CVD, coronary artery disease (CAD), and brain ischemic stroke in the Iranian population, categorized by gender.
Materials and Methods: The research involved 6985 participants from an Iranian cohort study. At the onset of the study, serum hs-CRP and RC levels were assessed. After ten years, occurrences of CVD, CAD, and brain ischemic events were evaluated. Furthermore, a survival and gender-stratified analysis was conducted to understand this association better.
Results: Participants with high RC but low hs-CRP had a 23.5% and 24% increase in CVD and CAD risk, while those with both elevated RC and hs-CRP had a 44.9% and 57% higher risk for CVD and CAD. Among women, the combination of elevated RC and hs-CRP was linked to a 36.7% increase in CAD risk. Survival analysis supported these findings, showing that individuals with elevated RC and hs-CRP levels had the shortest survival times for CVD (134.55 months) and CAD (135.30 months).
Conclusion: The combined use of RC and hs-CRP markers can strongly predict CVD and CAD, particularly in men. However, no association was found between RC and hs-CRP in brain ischemic stroke. To definitively address this issue, it is crucial to conduct future studies with a larger sample size that specifically target brain ischemic stroke.
(© 2025. The Author(s).)

Declarations. Ethical approval and consent to participate: Ethical Approval and Consent to participate -All individuals were well informed and their written consent was drawn. Accordingly, the study protocol was validated by the Ethics Committee of the Mashhad University of Medical Sciences (MUMS) and the Institutional Review Board of Mashhad University Medical Center. This project is supported by Mashhad University of Medical Sciences. Funding number: 4030900 and ethical approval cod: IR.MUMS.IRH.REC.1403.010. Consent for publication: This section as not applicable. It is not applicable to the Consent of Image Publication for this manuscript. The figures were designed only in this manuscript to present the results of the current paper. Competing interests: The Authors declare that there is no conflict of interest.

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4030900 Mashhad University of Medical Sciences

Keywords: Brain ischemic; Cardiovascular disease; Coronary artery disease; Remnant cholesterol; hs-CRP

9007-41-4 (C-Reactive Protein)
97C5T2UQ7J (Cholesterol)
0 (Biomarkers)

Date Created: 20250610 Date Completed: 20250610 Latest Revision: 20250613

20260130

PMC12150565

10.1186/s12944-025-02627-1

40495134