Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003-2010 and 2015-2018.

Publisher: BioMed Central Country of Publication: England NLM ID: 101217089 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5868 (Electronic) Linking ISSN: 14795868 NLM ISO Abbreviation: Int J Behav Nutr Phys Act Subsets: MEDLINE

Original Publication: [London] : BioMed Central, c2004-

Aging*/physiology ; Fasting* ; Nutrition Surveys* ; Feeding Behavior*; Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Time Factors ; United States ; Cross-Sectional Studies

Background: Information on the influences of daily eating frequency (DEF) and nighttime fasting duration (NFD) on biological aging is minimal. Our study investigated the potential associations of DEF and NFD with accelerated aging.
Methods: Out of 24212 participants in NHANES 2003-2010 and 2015-2018, 4 predicted age metrics [homeostatic dysregulation (HD), Klemera-Doubal method (KDM), phenoAge (PA), and allostatic load (AL)] were computed based on 12 blood chemistry parameters. Utilizing 24-h dietary recall, DEF was measured by the frequency of eating occurrences, while NFD was determined by assessing the timing of the initial and final meals throughout the day. Weighted multivariate linear regression models and restricted cubic spline (RCS) were utilized to examine the associations.
Results: Compared to DEF of ≤ 3.0 times, subjects with DEF ≥ 4.6 times demonstrated lower KDM residual [β: -0.57, 95% confidence-interval (CI): (-0.97, -0.17)] and PA residual [β: -0.47, 95% CI: (-0.69, -0.25)]. In comparison to NFD between 10.1 and 12.0 h, individuals with NFD ≤ 10.0 h were at higher HD [β: 0.03, 95% CI: (0.01, 0.04)], KDM residual [β: 0.34, 95% CI: (0.05, 0.63)], and PA residual [β: 0.38, 95% CI: (0.18, 0.57)]. Likewise, those with NFD ≥ 14.1 h also had higher HD [β: 0.02, 95% CI: (0.01, 0.04)] and KDM residual [β: 0.33, 95% CI: (0.03, 0.62)]. The results were confirmed by the dose-response relationships of DEF and NFD with predicted age metrics. Lactate dehydrogenase (LDH) and globulin (Glo) were acknowledged as implicated in and mediating the relationships.
Conclusions: DEF below 3.0 times and NFD less than 10.0 or more than 14.1 h were independently associated with higher predicted age metrics.
(© 2024. The Author(s).)

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Keywords: Biological aging; Daily eating frequency; National Health and Nutrition Examination Survey (NHANES); Nighttime fasting duration; Predicted age metrics

Date Created: 20240919 Date Completed: 20240920 Latest Revision: 20240922

20260130

PMC11414321

10.1186/s12966-024-01654-y

39300516