Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Interpreting urinary iodine concentration: effects of urine dilution and collection timing.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: London : J. Libbey, c1988-
    • الموضوع:
      Iodine*/urine ; Creatinine*/urine ; Urine Specimen Collection*/methods; Humans ; Female ; Adult ; Pregnancy ; Male ; Middle Aged ; Young Adult ; Time Factors ; Adolescent ; Aged
    • نبذة مختصرة :
      Objectives: In population studies, iodine intake estimation relies on median urinary iodine concentration (UIC). However, interpreting UIC measurements can be challenging.
      Methods: In our study, we included 772 adult participants from three groups: nationally representative gender-mixed, women of reproductive age, and pregnant women. We measured UIC and urinary creatinine (U-Cr) to calculate the iodine-to-creatinine ratio (I/Cr). U-Cr cut-off value of 0.226 g/L was used for differentiation between diluted and undiluted urine samples. After excluding samples below this cut-off, new median UIC and I/Cr ratios were calculated. We additionally evaluated the influence of urine sample collection time on UIC.
      Results: Median UICs were 91.8 µg/L for nationally representative group, 58.3 µg/L for women of reproductive age, and 74.9 µg/L for pregnant women, while I/Cr ratios were 91.7, 102.0, and 159.2 µg/g, respectively. After implementing U-Cr cut-off and excluding all data where U-Cr was below cut-off, new median values were 93.4, 76.3, and 95.4 µg/L for UICs, and 88.6, 88.8, and 128.7 µg/g for I/Cr ratios, respectively. In women of reproductive age, median UIC was significantly lower in urine samples collected after 9:30 and after 12:00 as compared to samples collected before 9.30 (53.4, 57.8, and 97.3 μg/L, respectively).
      Conclusions: UIC results should be interpreted with caution, considering urine dilution and sample collection timing. U-Cr measurement should be included in population-based iodine intake studies, with corrections applied especially for pregnant women and younger adults, for whom morning is best for single-spot samples.
      (© 2024. The Author(s).)
    • نبذة مختصرة :
      Competing interests: The authors declare no competing interests. Ethics approval: The Nutrihealth and EUthyroid studies were approved by the Slovenian National Medical Ethics Committee (Ministry of Health, Republic of Slovenia). Nutrihealth study had identification number 0120-337/2016-4 and was registered at ClinicalTrials.gov (ID: NCT03284840). EUthyroid study had identification number 0120-508/2017-2.
    • References:
      Clin Chem Lab Med. 2017 Aug 28;55(9):e206-e208. (PMID: 28306524)
      NCHS Data Brief. 2016 Apr;(242):1-8. (PMID: 27139510)
      Clin Chem Lab Med. 2020 Jan 28;58(2):e32-e35. (PMID: 31352432)
      Acta Chim Slov. 2021 Jun;68(2):488-493. (PMID: 34738129)
      Forensic Sci Int. 2009 Apr 15;186(1-3):48-51. (PMID: 19216038)
      Thyroid. 2014 Apr;24(4):748-57. (PMID: 24308769)
      Endocr Rev. 2009 Jun;30(4):376-408. (PMID: 19460960)
      Croat Med J. 2011 Oct 15;52(5):615-21. (PMID: 21990079)
      Drug Test Anal. 2017 Jun;9(6):853-865. (PMID: 28267298)
      Nutrients. 2022 Sep 01;14(17):. (PMID: 36079875)
      Endocr J. 1993 Feb;40(1):163-9. (PMID: 7951490)
      Br J Nutr. 2008 Apr;99(4):813-8. (PMID: 17961291)
      Scand J Clin Lab Invest Suppl. 2000;231:1-86. (PMID: 12647764)
      Eur J Clin Nutr. 1999 May;53(5):401-7. (PMID: 10369497)
      Eur J Clin Nutr. 2000 Apr;54(4):361-3. (PMID: 10745289)
      Expert Rev Clin Immunol. 2011 Sep;7(5):697-706; quiz 707. (PMID: 21895480)
      Thyroid. 2009 Nov;19(11):1281-6. (PMID: 19888863)
      Int J Environ Res Public Health. 2021 Mar 19;18(6):. (PMID: 33808539)
      Thyroid. 2020 Sep;30(9):1346-1354. (PMID: 32460688)
      Biochem Med (Zagreb). 2014 Feb 15;24(1):89-104. (PMID: 24627718)
      Lab Med. 2022 Jul 4;53(4):376-380. (PMID: 35073580)
    • Grant Information:
      L3-8213 The Slovenian Research and Innovation Agency (ARIS); 634453 EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020); 634435 EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
    • الرقم المعرف:
      9679TC07X4 (Iodine)
      AYI8EX34EU (Creatinine)
    • الموضوع:
      Date Created: 20240808 Date Completed: 20241202 Latest Revision: 20241205
    • الموضوع:
      20260130
    • الرقم المعرف:
      PMC11611732
    • الرقم المعرف:
      10.1038/s41430-024-01492-y
    • الرقم المعرف:
      39117906