Tackling Losartan Contamination: The Promise of Peroxymonosulfate/Fe(II) Advanced Oxidation Processes.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Losartan*/chemistry ; Oxidation-Reduction* ; Water Pollutants, Chemical*/chemistry ; Peroxides*/chemistry ; Water Purification*/methods; Iron/chemistry ; Wastewater/chemistry ; Catalysis ; Kinetics

Losartan, an angiotensin II receptor antagonist frequently detected in wastewater effluents, poses considerable risks to both aquatic ecosystems and human health. Seeking to address this challenge, advanced oxidation processes (AOPs) emerge as robust methodologies for the efficient elimination of such contaminants. In this study, the degradation of Losartan was investigated in the presence of activated peroxymonosulfate (PMS), leveraging ferrous iron as a catalyst to enhance the oxidation process. Utilizing advanced analytical techniques such as NMR and mass spectrometry, nine distinct byproducts were characterized. Notably, seven of these byproducts were identified for the first time, providing novel insights into the degradation pathway of Losartan. The study delved into the kinetics of the degradation process, assessing the degradation efficiency attained when employing the catalyst alone versus when using it in combination with PMS. The results revealed that Losartan degradation reached a significant level of 64%, underscoring the efficacy of PMS/Fe(II) AOP techniques as promising strategies for the removal of Losartan from water systems. This research not only enriches our understanding of pollutant degradation mechanisms, but also paves the way for the development of sustainable water treatment technologies, specifically targeting the removal of pharmaceutical contaminants from aquatic environments.

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Keywords: advanced oxidation processes; degradation byproducts; losartan; peroxymonosulfate; water treatment

JMS50MPO89 (Losartan)
22047-43-4 (peroxymonosulfate)
0 (Water Pollutants, Chemical)
0 (Peroxides)
E1UOL152H7 (Iron)
0 (Wastewater)

Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527

20250114

PMC11123791

10.3390/molecules29102237

38792099