The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Polymers* ; Lung Injury* ; Acrylates*; Rats ; Animals ; Rats, Inbred F344 ; Endoplasmic Reticulum Stress ; Inflammation ; Lung

Polyacrylic acid (PAA), an organic chemical, has been used as an intermediate in the manufacture of pharmaceuticals and cosmetics. It has been suggested recently that PAA has a high pulmonary inflammatory and fibrotic potential. Although endoplasmic reticulum stress is induced by various external and intracellular stimuli, there have been no reports examining the relationship between PAA-induced lung injury and endoplasmic reticulum stress. F344 rats were intratracheally instilled with dispersed PAA (molecular weight: 269,000) at low (0.5 mg/mL) and high (2.5 mg/mL) doses, and they were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months after exposure. PAA caused extensive inflammation and fibrotic changes in the lungs' histopathology over a month following instillation. Compared to the control group, the mRNA levels of endoplasmic reticulum stress markers Bip and Chop in BALF were significantly increased in the exposure group. In fluorescent immunostaining, both Bip and Chop exhibited co-localization with macrophages. Intratracheal instillation of PAA induced neutrophil inflammation and fibrosis in the rat lung, suggesting that PAA with molecular weight 269,000 may lead to pulmonary disorder. Furthermore, the presence of endoplasmic reticulum stress in macrophages was suggested to be involved in PAA-induced lung injury.

Chest. 2012 Apr;141(4):1110-1113. (PMID: 22474155)
Part Fibre Toxicol. 2022 Apr 8;19(1):27. (PMID: 35395797)
Sci Rep. 2017 Oct 27;7(1):14272. (PMID: 29079731)
Int Rev Cell Mol Biol. 2021;363:1-20. (PMID: 34392927)
J Biol Chem. 2014 Nov 28;289(48):33391-403. (PMID: 25324550)
Biomedicines. 2022 Jun 25;10(7):. (PMID: 35884806)
Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901. (PMID: 23885834)
PLoS One. 2023 Apr 21;18(4):e0284837. (PMID: 37083639)
Annu Rev Pathol. 2015;10:173-94. (PMID: 25387057)
Hepatology. 2023 Feb 1;77(2):619-639. (PMID: 35524448)
Int J Chron Obstruct Pulmon Dis. 2015 Dec 22;11:31-41. (PMID: 26730186)
J Emerg Med. 2014 Jul;47(1):15-7. (PMID: 24462024)
J Clin Pathol. 1988 Apr;41(4):467-70. (PMID: 3366935)
Environ Health Perspect. 1990 Aug;88:305-9. (PMID: 2272327)
Nanomaterials (Basel). 2020 Oct 15;10(10):. (PMID: 33076408)
Am J Respir Crit Care Med. 2008 Oct 15;178(8):838-46. (PMID: 18635891)
Int J Mol Sci. 2021 Nov 10;22(22):. (PMID: 34830058)
Int J Mol Sci. 2016 Aug 01;17(8):. (PMID: 27490535)
Open Life Sci. 2020 Aug 18;15(1):598-605. (PMID: 33817248)
Exp Pathol. 1987;32(3):129-52. (PMID: 3436395)
Part Fibre Toxicol. 2022 Jan 21;19(1):8. (PMID: 35062982)
Oncology (Williston Park). 2002 Feb;16(2):217-26, 229; discussion 230-2. (PMID: 11866137)
J Periodontal Res. 2022 Oct;57(5):915-932. (PMID: 35818935)
J Pathol. 2016 Aug;239(4):411-25. (PMID: 27135434)
Inhal Toxicol. 2003 Oct;15(12):1147-77. (PMID: 14515220)
Sci Total Environ. 2017 Oct 15;596-597:53-60. (PMID: 28415004)
Environ Health Perspect. 1992 Jul;97:189-91. (PMID: 1396457)
Nanotoxicology. 2016;10(5):607-18. (PMID: 26558952)
Clin Transl Immunology. 2018 Jun 13;7(6):e1019. (PMID: 29928501)
Toxicol Lett. 1996 Nov;88(1-3):109-13. (PMID: 8920724)
Fundam Appl Toxicol. 1991 Aug;17(2):280-99. (PMID: 1662648)
Am J Respir Cell Mol Biol. 2012 Jun;46(6):731-9. (PMID: 21852685)
J Toxicol Environ Health A. 2016;79(2):49-60. (PMID: 26818398)
Eur Respir Rev. 2017 Jun 28;26(144):. (PMID: 28659504)
Matrix Biol. 2018 Aug;68-69:355-365. (PMID: 29567124)
Langmuir. 2014 Jan 14;30(1):308-17. (PMID: 24354390)
Indoor Air. 2019 Sep;29(5):735-747. (PMID: 31278778)
Inhal Toxicol. 2001 Jul;13(7):603-21. (PMID: 11452357)
Oncotarget. 2017 Nov 16;8(63):106429-106442. (PMID: 29290960)
Nat Rev Nephrol. 2017 Nov;13(11):681-696. (PMID: 28970584)
Mol Ther. 2016 May;24(5):915-25. (PMID: 26883801)
Toxicol Lett. 2020 Oct 15;333:140-149. (PMID: 32755622)
Int J Mol Sci. 2022 Nov 10;23(22):. (PMID: 36430349)
J Comp Pathol. 2020 Nov;181:86-91. (PMID: 33288157)
Int J Mol Sci. 2022 Sep 07;23(18):. (PMID: 36142256)

200101-01 The Ministry of Health, Labour and Welfare

Keywords: endoplasmic reticulum stress; fibrosis; molecular weight; organic compounds; persistent inflammation; polyacrylic acid (PAA); pulmonary toxicity

0 (Polymers)
J94PBK7X8S (acrylic acid)
0 (Acrylates)

Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425

20250114

PMC11011863

10.3390/ijms25073573

38612383