Performance of radiomics-based artificial intelligence systems in the diagnosis and prediction of treatment response and survival in esophageal cancer: a systematic review and meta-analysis of diagnostic accuracy.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 8809160 Publication Model: Print Cited Medium: Internet ISSN: 1442-2050 (Electronic) Linking ISSN: 11208694 NLM ISO Abbreviation: Dis Esophagus Subsets: MEDLINE

Publication: 2017- : New York : Oxford University Press
Original Publication: Milano : Masson, 1988-

Positron Emission Tomography Computed Tomography*/methods ; Esophageal Neoplasms*/diagnostic imaging ; Esophageal Neoplasms*/therapy; Humans ; Fluorodeoxyglucose F18 ; Artificial Intelligence ; Radiomics

Radiomics can interpret radiological images with more detail and in less time compared to the human eye. Some challenges in managing esophageal cancer can be addressed by incorporating radiomics into image interpretation, treatment planning, and predicting response and survival. This systematic review and meta-analysis provides a summary of the evidence of radiomics in esophageal cancer. The systematic review was carried out using Pubmed, MEDLINE, and Ovid EMBASE databases-articles describing radiomics in esophageal cancer were included. A meta-analysis was also performed; 50 studies were included. For the assessment of treatment response using 18F-FDG PET/computed tomography (CT) scans, seven studies (443 patients) were included in the meta-analysis. The pooled sensitivity and specificity were 86.5% (81.1-90.6) and 87.1% (78.0-92.8). For the assessment of treatment response using CT scans, five studies (625 patients) were included in the meta-analysis, with a pooled sensitivity and specificity of 86.7% (81.4-90.7) and 76.1% (69.9-81.4). The remaining 37 studies formed the qualitative review, discussing radiomics in diagnosis, radiotherapy planning, and survival prediction. This review explores the wide-ranging possibilities of radiomics in esophageal cancer management. The sensitivities of 18F-FDG PET/CT scans and CT scans are comparable, but 18F-FDG PET/CT scans have improved specificity for AI-based prediction of treatment response. Models integrating clinical and radiomic features facilitate diagnosis and survival prediction. More research is required into comparing models and conducting large-scale studies to build a robust evidence base.
(© The Author(s) 2023. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus.)

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Keywords: esophageal cancers; radiology; robotics

0Z5B2CJX4D (Fluorodeoxyglucose F18)

Date Created: 20230526 Date Completed: 20240116 Latest Revision: 20240117

20250114

PMC10789236

10.1093/dote/doad034

37236811