Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Phylogeny*; Cat Diseases/*epidemiology ; Morbillivirus/*classification ; Morbillivirus/*pathogenicity ; Morbillivirus Infections/*epidemiology ; Morbillivirus Infections/*veterinary ; Renal Insufficiency, Chronic/*veterinary; Animals ; Cat Diseases/virology ; Cats ; Female ; Italy/epidemiology ; Kidney/virology ; Male ; Morbillivirus/genetics ; Prevalence ; RNA, Viral/genetics ; Renal Insufficiency, Chronic/epidemiology

Feline morbillivirus (FeMV) was isolated for the first time in 2012 with an association with chronic kidney disease (CKD) suggested. This study aimed at investigating in cats from southern Italy FeMV prevalence and risk factors for exposure to FeMV, including the relationship with CKD; sequencing amplicons and analyzing phylogeny of PCR positive samples. Blood serum, K 3 EDTA blood and urine samples from 223 cats were investigated. Ten carcasses were also evaluated. FeMV RNA was detected in 2.4% (5/211) blood and 16.1% (36/223) urine samples. One carcass tested positive by qPCR FeMV from kidney, urinary bladder, and submandibular lymph nodes. Antibodies against FeMV were detected in 14.5% (28/193) cats. We followed up 27 cats (13 FeMV positive cats) and documented in some cases urine shedding after up to 360 days. Older and foundling cats and cats living in rescue catteries, were more frequently infected with FeMV. A significant correlation between FeMV and higher serum creatinine values or low urine specific gravity was found. FeMV positivity was significantly associated with retroviral infection, and the presence of some clinical signs apart from CKD clinicopathological markers. Our study highlights the possibility of a link between FeMV exposure and CKD and a general impairment of feline health.

Viruses. 2015 Feb 12;7(2):699-706. (PMID: 25685949)
J Feline Med Surg. 2009 Jul;11(7):575-84. (PMID: 19481037)
Vet Microbiol. 2019 Sep;236:108382. (PMID: 31500720)
Arch Virol. 2017 Feb;162(2):469-475. (PMID: 27804021)
J Feline Med Surg. 2010 Oct;12(10):746-53. (PMID: 20685143)
Braz J Microbiol. 2021 Jun;52(2):961-965. (PMID: 33483894)
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5435-40. (PMID: 22431644)
Animals (Basel). 2020 May 10;10(5):. (PMID: 32397661)
J Feline Med Surg. 2014 Jun;16(6):465-72. (PMID: 24217707)
J Feline Med Surg. 2017 Dec;19(12):1206-1214. (PMID: 28112564)
BMC Vet Res. 2020 Jul 13;16(1):240. (PMID: 32660481)
J Gen Virol. 2008 Sep;89(Pt 9):2290-2298. (PMID: 18753239)
Mol Biol Evol. 2013 Apr;30(4):772-80. (PMID: 23329690)
Emerg Infect Dis. 2016 Apr;22(4):760-2. (PMID: 26982566)
Arch Virol. 2014 Feb;159(2):371-3. (PMID: 23929233)
J Vet Intern Med. 2014 Nov-Dec;28(6):1676-83. (PMID: 25231385)
Arch Virol. 2021 Jan;166(1):281-285. (PMID: 33216214)
Vet Microbiol. 2019 Jan;228:12-19. (PMID: 30593357)
Viruses. 2021 Apr 15;13(4):. (PMID: 33921104)
Virus Genes. 2015 Oct;51(2):294-7. (PMID: 26265247)
Viruses. 2021 Mar 30;13(4):. (PMID: 33808115)
J Vet Intern Med. 2008 Mar-Apr;22(2):317-24. (PMID: 18371026)
J Feline Med Surg. 2021 Jun;23(6):584-591. (PMID: 33140998)
Transbound Emerg Dis. 2020 Dec 9;:. (PMID: 33295141)
Vet Ital. 2019 Jun 30;55(2):179-182. (PMID: 31274181)
Arch Virol. 2016 Aug;161(8):2351-60. (PMID: 27216929)
Arch Virol. 2020 Aug;165(8):1837-1841. (PMID: 32447623)
Vet Ital. 2015 Jul-Sep;51(3):235-7. (PMID: 26269317)
J Virol Methods. 2016 Aug;234:160-3. (PMID: 27155238)
BMC Vet Res. 2016 Oct 11;12(1):228. (PMID: 27724851)
Cytopathology. 2016 Oct;27(5):359-68. (PMID: 27146425)
J Vet Med Sci. 2015 May;77(5):565-9. (PMID: 25649267)
Vet Microbiol. 2019 Jun;233:133-139. (PMID: 31176399)
J Virol Methods. 2018 Aug;258:24-28. (PMID: 29730392)
J Feline Med Surg. 2016 Mar;18(3):219-39. (PMID: 26936494)
J Vet Med Sci. 2016 Jan;77(12):1701-3. (PMID: 26227478)
Virology. 2014 Nov;468-470:524-531. (PMID: 25262470)
Mol Biol Evol. 1993 May;10(3):512-26. (PMID: 8336541)
Vet Microbiol. 2020 Jan;240:108484. (PMID: 31902482)
Viruses. 2020 May 01;12(5):. (PMID: 32370044)
Viruses. 2019 Feb 09;11(2):. (PMID: 30744110)
J Vet Intern Med. 2018 May;32(3):1100-1108. (PMID: 29572949)
Mol Biol Evol. 2016 Jul;33(7):1870-4. (PMID: 27004904)
J Gen Virol. 2014 Jul;95(Pt 7):1464-1468. (PMID: 24728711)
J Feline Med Surg. 2019 Jan;21(1):5-11. (PMID: 30472918)

Keywords: CKD; FeMV; IIF; PCR; cat; chronic kidney disease; epidemiology; feline morbillivirus; paramyxovirus

0 (RNA, Viral)

Feline morbillivirus

Date Created: 20210828 Date Completed: 20220203 Latest Revision: 20220203

20250114

PMC8402783

10.3390/v13081449

34452315