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Increased rates of diphenhydramine overdose, abuse, and misuse in the United States, 2005-2016.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101241654 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-9519 (Electronic) Linking ISSN: 15563650 NLM ISO Abbreviation: Clin Toxicol (Phila) Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Philadelphia, PA : Taylor & Francis, c2005-
    • الموضوع:
      Diphenhydramine/*poisoning ; Drug Misuse/*trends ; Drug Overdose/*epidemiology ; Illicit Drugs/*poisoning ; Nonprescription Drugs/*poisoning ; Suicide, Attempted/*trends; Adolescent ; Adult ; Aged ; Child ; Drug Overdose/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Time Factors ; United States/epidemiology ; Young Adult
    • نبذة مختصرة :
      Objectives: To describe trends in abuse, misuse, and suicide attempts involving diphenhydramine (DPH).
      Methods: We analyzed intentional DPH exposures of individuals ≥10 years old reported to U.S. Poison Control Centers using data from the National Poison Data System, 2005-2016.
      Results: There were 158,774 intentional DPH exposures in our dataset. The rate of intentional exposures increased 63% over the 12-year study period for all ages combined. Suicide attempts involving DPH showed a bimodal distribution-increasing 263% among children 10-14 years of age, and 126 and 143% among those 55-64 and ≥65 years of age, respectively. Older adults in both the 55-64 and ≥65-year-old age groups had about a 230% increase in rates of misuse. Major adverse clinical effects increased by 91%. There were 745 total reported deaths with a 3.6% increase across all age groups.
      Conclusions: Intentional DPH exposures among individuals ≥10 years old have been increasing since 2005. Increasing rates of suicide attempts among children ages 10-14 and increasing misuse among individuals ≥65, coupled with a trend toward greater severity of overdoses, highlight the significant public health impact of this commonly available over-the-counter drug.
    • Contributed Indexing:
      Keywords: Benadryl; Diphenhydramine; abuse; misuse; suicide
    • الرقم المعرف:
      0 (Illicit Drugs)
      0 (Nonprescription Drugs)
      8GTS82S83M (Diphenhydramine)
    • الموضوع:
      Date Created: 20210310 Date Completed: 20211108 Latest Revision: 20220427
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/15563650.2021.1892716
    • الرقم المعرف:
      33688782