The association of rs11457523 in HSP90AA1 with idiopathic male infertility in the Chinese population.

Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0272 (Electronic) Linking ISSN: 03034569 NLM ISO Abbreviation: Andrologia Subsets: MEDLINE

Publication: : Berlin : Blackwell Pub.
Original Publication: Berlin, Grosse

Infertility, Male*/genetics; Case-Control Studies ; China/epidemiology ; Genotype ; HSP90 Heat-Shock Proteins/genetics ; Humans ; Male ; Polymorphism, Single Nucleotide ; Semen ; Sperm Count ; Spermatozoa

The association of single nucleotide polymorphisms (SNPs) in heat shock protein 90 (HSP90) genes with idiopathic male infertility remains unclear. In this study, the five selected SNPs in HSP90AA1 namely rs10133307, rs10873531, rs11547523, rs11621560 and rs7145597 were genotyped in 116 idiopathic infertile males and 185 ethnically matched fertile males using the Sequenom MassARRAY assay. The role of these SNPs in male infertility was then studied using multiple genetic models. We observed that genotype distribution (p = .028) and allelic frequency (p = .032) of rs11547523 were significantly different between the infertile and fertile groups. In particular, A genotype of rs11547523 was associated with an increased risk of infertility in the allele (OR = 2.508, p = .048), dominant (OR = 2.733, p = .030) and additive models (OR = 0.366, p = .031). However, there were no significant differences in semen parameters including seminal volume (p = .452), sperm concentration (p = .727), total sperm number (p = .588), motility (p = .282) and morphology (p = .975) between A and A/G genotypes of rs11547523. These results indicate that rs11547523 in HSP90AA1 may be associated with idiopathic male infertility in the Chinese population. The outcome of this study contributes to the development of the diagnosis of male infertility.
(© 2020 Wiley-VCH GmbH.)

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81801525 National Natural Science Foundation of China; LY17H040002 Natural Science Foundation of Zhejiang Province; LQ17H040004 Natural Science Foundation of Zhejiang Province; C11920D-04 Special Project for the Research Institutions of Zhejiang Province; Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents; 2018C37126 Sci&Tech Program Project of Zhejiang Province; 2019KY363 Health Sci&Tech Plan Project of Zhejiang Province; 2018KY039 Health Sci&Tech Plan Project of Zhejiang Province

Keywords: heat shock protein 90; male infertility; semen; single nucleotide polymorphisms; spermatozoa

0 (HSP90 Heat-Shock Proteins)
0 (HSP90AA1 protein, human)

Date Created: 20201109 Date Completed: 20210621 Latest Revision: 20220531

20250114

10.1111/and.13888

33167063