EMAC, Retromer, and VSRs: do they connect?

Publisher: Springer Country of Publication: Austria NLM ID: 9806853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-6102 (Electronic) Linking ISSN: 0033183X NLM ISO Abbreviation: Protoplasma Subsets: MEDLINE

Publication: <1998->: Wien ; New York : Springer
Original Publication: Leipzig : Verlag von Gebrüder Borntraeger, 1927-

Biological Transport/*physiology ; Golgi Apparatus/*chemistry ; Sorting Nexins/*chemistry ; Vacuoles/*chemistry

Eukaryotic organisms share many common features in terms of endomembrane trafficking. This fact has helped plant scientists to propose testable hypotheses on how plant intracellular membrane trafficking is achieved and regulated based on knowledge from yeast and mammals. However, when a new compartment has been identified in a plant cell that has a vesicle tethering complex located at a position which is completely different to its counterpart in yeast and mammalian cells, caution is demanded when interpreting possible interactions with other trafficking elements. This is exemplified by the recently discovered EMAC (ER and microtubule-associated compartment). It has been postulated that this compartment is the recipient of vacuolar sorting receptors (VSRs) transported retrogradely via "retromer vesicles" from a post-Golgi location. Unfortunately, this suggestion was based entirely on our knowledge of retromer from yeast and mammalian cells, and did not take into account the available literature on the composition, localization, and function of the plant retromer. It also lacked reference to recent contradictory findings on VSR trafficking. In this short article, we have tried to rectify this situation, pointing out that plant retromer may not function as a pentameric complex of two subunits: the retromer core and the sorting nexins.

Erratum in: Protoplasma. 2021 Sep;258(5):1163. doi: 10.1007/s00709-021-01688-0. (PMID: 34273016)

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267205415 Deutsche Forschungsgemeinschaft

Keywords: Endomembrane trafficking; Retromer; SNX; Sorting nexin; Subcellular localization; VPS26-VPS35-VPS29

0 (Sorting Nexins)

Date Created: 20200812 Date Completed: 20210713 Latest Revision: 20210723

20250114

PMC8286218

10.1007/s00709-020-01543-8

32780164