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Pseudomonas infections among hospitalized adults in Latin America: a systematic review and meta-analysis.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Anti-Bacterial Agents/*therapeutic use ; Pseudomonas Infections/*drug therapy ; Pseudomonas Infections/*mortality; Adult ; Comorbidity ; Drug Resistance, Bacterial ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units ; Latin America/epidemiology ; Pseudomonas aeruginosa/drug effects
    • نبذة مختصرة :
      Background: Treatment of resistant Pseudomonas aeruginosa infection continues to be a challenge in Latin American countries (LATAM). We synthesize the literature on the use of appropriate initial antibiotic therapy (AIAT) and inappropriate initial antibiotic therapy (IIAT) in P. aeruginosa infections, and the literature on risk factors for acquisition of resistant P. aeruginosa among hospitalized adult patients in LATAM.
      Methods: MEDLINE, EMBASE, Cochrane, and LILAC were searched between 2000 and August 2019. Abstracts and full-text articles were screened in duplicate. Random effects meta-analysis was conducted when studies were sufficiently similar.
      Results: The screening of 165 citations identified through literature search yielded 98 full-text articles that were retrieved and assessed for eligibility, and 19 articles conducted in Brazil (14 articles), Colombia (4 articles), and Cuba (1 article) met the inclusion criteria. Of 19 eligible articles, six articles (840 subjects) examined AIAT compared to IIAT in P. aeruginosa infections; 17 articles (3203 total subjects) examined risk factors for acquisition of resistant P. aeruginosa; and four articles evaluated both. Four of 19 articles were rated low risk of bias and the remaining were deemed unclear or high risk of bias. In meta-analysis, AIAT was associated with lower mortality for P. aeruginosa infections (unadjusted summary OR 0.48, 95% CI 0.28-0.81; I 2  = 59%), compared to IIAT and the association with mortality persisted in subgroup meta-analysis by low risk of bias (3 articles; unadjusted summary OR 0.46, 95% CI 0.28-0.81; I 2  = 0%). No meta-analysis was performed for studies evaluating risk factors for acquisition of resistant P. aeruginosa as they were not sufficiently similar. Significant risk factors for acquisition of resistant P. aeruginosa included: prior use of antibiotics (11 articles), stay in the intensive care unit (ICU) (3 articles), and comorbidity score (3 articles). Outcomes were graded to be of low strength of evidence owing to unclear or high risk of bias and imprecise estimates.
      Conclusion: Our study highlights the association of AIAT with lower mortality and prior use of antibiotics significantly predicts acquiring resistant P. aeruginosa infections. This review reinforces the need for rigorous and structured antimicrobial stewardship programs in the LATAM region.
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    • Grant Information:
      NA Merck Sharp and Dohme
    • Contributed Indexing:
      Keywords: Antibiotic therapy; Appropriate; Inappropriate; Latin America; Pseudomonas aeruginosa; Resistance; Risk factors
    • الرقم المعرف:
      0 (Anti-Bacterial Agents)
    • الموضوع:
      Date Created: 20200330 Date Completed: 20200529 Latest Revision: 20200529
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC7099820
    • الرقم المعرف:
      10.1186/s12879-020-04973-0
    • الرقم المعرف:
      32220233