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The association of lecithin retinol acyltransferase and the 25(OH)D receptor with pediatric overweight and obesity.

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  • المؤلفون: Liang X;Liang X; He Y; He Y; Chen M; Chen M; Ping Q; Ping Q; Chen J; Chen J
  • المصدر:
    European journal of clinical nutrition [Eur J Clin Nutr] 2019 Dec; Vol. 73 (12), pp. 1626-1629. Date of Electronic Publication: 2019 Apr 09.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: London : J. Libbey, c1988-
    • الموضوع:
      Overweight*/blood ; Overweight*/epidemiology ; Pediatric Obesity*/blood ; Pediatric Obesity*/epidemiology; Acyltransferases/*blood ; Receptors, Calcitriol/*blood ; Vitamin D/*analogs & derivatives; Child ; Cohort Studies ; Female ; Humans ; Male ; Vitamin A/blood ; Vitamin D/blood
    • نبذة مختصرة :
      The aim of this study is to determine whether lecithin retinol acyltransferase (LRAT) as well as biomarkers of vitamin A (VA) and vitamin D are related to indices of obesity in childhood. A total of 164 children (aged 6-12 years, female 49.39%), comprising 66 children in the overweight/obese group and 98 children in the lean group, were included. LRAT expression was remarkably lower in the overweight/obese group than in the lean group (P < 0.01). Compared with the lean group, the overweight/obese group had elevated VA (0.95 ± 0.25 vs. 0.83 ± 0.21 µmol/L, P < 0.01). Moreover, the levels of 25(OH)D (25-hydroxyvitamin D) and its receptor were lower in overweight/obese subjects than in lean subjects (P = 0.06 and <0.05). LRAT was negatively correlated with body mass index and waist circumference (R = -0.27, P < 0.01, and R = -0.18, P < 0.05, respectively) and positively correlated with high-density lipoprotein (R = 0.18, P < 0.05). VA metabolism may be disordered in obese children, although children with obesity have higher VA levels than lean children.
    • Grant Information:
      2014M562289 International China Postdoctoral Science Foundation; 81502826 International National Natural Science Foundation of China (National Science Foundation of China)
    • الرقم المعرف:
      0 (Receptors, Calcitriol)
      11103-57-4 (Vitamin A)
      1406-16-2 (Vitamin D)
      A288AR3C9H (25-hydroxyvitamin D)
      EC 2.3.- (Acyltransferases)
      EC 2.3.1.- (lecithin-retinol acyltransferase)
    • الموضوع:
      Date Created: 20190411 Date Completed: 20200921 Latest Revision: 20200921
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1038/s41430-019-0422-0
    • الرقم المعرف:
      30967641