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Borrelia burgdorferi surface-located Lmp1 protein processed into region-specific polypeptides that are critical for microbial persistence.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Country of Publication: United States NLM ID: 100883691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-5822 (Electronic) Linking ISSN: 14625814 NLM ISO Abbreviation: Cell Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2024- : [Hoboken, NJ] : Wiley
      Original Publication: Oxford : Wiley-Blackwell, c1999-
    • الموضوع:
      Microbial Viability* ; Protein Processing, Post-Translational*; Bacterial Proteins/*metabolism ; Borrelia burgdorferi/*physiology ; Membrane Proteins/*metabolism ; Serine Proteases/*metabolism ; Virulence Factors/*metabolism; Animals ; Mice ; Proteolysis ; Ticks
    • نبذة مختصرة :
      One of the Borrelia burgdorferi virulence determinants, annotated as Lmp1, is a surface-exposed, conserved, and potential multi-domain protein involved in various functions in spirochete infectivity. Lmp1 contributes to host-pathogen interactions and evasion of host adaptive immunity by spirochetes. Here, we show that in diverse B. burgdorferi species, Lmp1 exists as distinct, region-specific, and lower molecular mass polypeptides encompassing 1 or more domains, including independent N-terminal and middle regions and a combined middle and C-terminal region. These polypeptides originate from complex posttranslational maturation events, partly supported by a periplasmic serine protease termed as BbHtrA. Although spirochete persistence in mice is independently supported by domain-specific Lmp1 polypeptides, transmission of B. burgdorferi from ticks to mammals requires essential contributions from both N-terminal and middle regions. Interference with the functions of Lmp1 domains or their complex posttranslational maturation events may aid in development of novel therapeutic strategies to combat infection and transmission of pathogens.
      (© 2018 John Wiley & Sons Ltd.)
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    • Grant Information:
      R01 AI116620 United States AI NIAID NIH HHS; R03 AI103894 United States AI NIAID NIH HHS; R01 AI080615 United States AI NIAID NIH HHS; P01 AI138949 United States AI NIAID NIH HHS; R03 AI092143 United States AI NIAID NIH HHS
    • Contributed Indexing:
      Keywords: Lmp1; Lyme disease, Borrelia burgdorferi; host persistence; protease pathogen; protein processing; transmission
    • الرقم المعرف:
      0 (Bacterial Proteins)
      0 (Membrane Proteins)
      0 (Virulence Factors)
      EC 3.4.- (Serine Proteases)
    • الموضوع:
      Date Created: 20180512 Date Completed: 20190715 Latest Revision: 20190901
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC6113067
    • الرقم المعرف:
      10.1111/cmi.12855
    • الرقم المعرف:
      29749010