Effect of plasma amino acid and hormone concentrations on renal plasma flow and glomerular filtration rate.

Publisher: S. Karger Country of Publication: Switzerland NLM ID: 8402040 Publication Model: Print Cited Medium: Print ISSN: 0253-5068 (Print) Linking ISSN: 02535068 NLM ISO Abbreviation: Blood Purif Subsets: MEDLINE

Original Publication: Basel ; New York : S. Karger, [c1983-

Amino Acids/*blood ; Dietary Proteins/*pharmacology ; Glomerular Filtration Rate/*drug effects ; Glucagon/*blood ; Growth Hormone/*blood ; Insulin/*blood ; Renal Circulation/*drug effects ; Somatostatin/*blood; Adult ; Amino Acids/pharmacology ; Dietary Proteins/administration & dosage ; Drug Interactions ; Glucagon/pharmacology ; Growth Hormone/pharmacology ; Humans ; Insulin/pharmacology ; Regional Blood Flow/drug effects ; Somatostatin/pharmacology ; Stimulation, Chemical

The effect of amino acid infusion on renal hemodynamics was examined in 13 healthy subjects. Seven subjects participated in the first experimental protocol: study 1 - amino acids were infused for 3 h to increase plasma amino acid levels 2- to 3-fold above baseline; study 2 - amino acids were infused with somatostatin and peripheral replacement of insulin, glucagon and growth hormone; and study 3 - somatostatin and hormones were infused as in study 2, but no amino acids were infused. During study 1 both glomerular filtration rate (GFR) and renal plasma flow (RPF) increased by 20%. In contrast, when amino acids were infused with somatostatin (study 2), neither GFR nor RPF changed from baseline. In study 3, somatostatin alone had no effect on GFR and RPF. In a second experimental protocol, 6 subjects were maintained for 7 days on a low protein diet (40 g/day); amino acids were infused as in study 1 before and after the protein restriction. Baseline GFR and RPF both decreased significantly after protein restriction. The response to amino acid infusion was not changed. These results indicate that: (1) hyperaminoacidemia causes a rise in both GFR and RPF; (2) the increase is likely to be mediated by some hormones whose secretion is inhibited by somatostatin, and (3) protein restriction causes a decline in GFR and RPF but fails to alter the renal hemodynamic response to amino acid infusion.

0 (Amino Acids)
0 (Dietary Proteins)
0 (Insulin)
51110-01-1 (Somatostatin)
9002-72-6 (Growth Hormone)
9007-92-5 (Glucagon)

Date Created: 19880101 Date Completed: 19890210 Latest Revision: 20180215

20250114

10.1159/000169550

2905139