Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study.

Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Publication: 2024- : [Hoboken, NJ] : Wiley
Original Publication: New York, NY : Hindawi Pub. Co.

Blood Viscosity*/drug effects ; Cerebrovascular Disorders*/blood ; Cerebrovascular Disorders*/drug therapy ; Cerebrovascular Disorders*/physiopathology ; Pyrithioxin*/administration & dosage ; Vinca Alkaloids*/administration & dosage; Blood Proteins/biosynthesis ; Aged ; Female ; Humans ; Male ; Middle Aged ; Drug Synergism ; Erythrocytes ; Rheology

Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.

Br J Haematol. 2008 Jun;141(6):852-61. (PMID: 18371109)
Clin Chem. 2010 May;56(5):781-8. (PMID: 20348406)
Vasc Health Risk Manag. 2009;5(2):483-8. (PMID: 19554088)
Int J Artif Organs. 2009 Jun;32(6):329-35. (PMID: 19670184)
Scand Cardiovasc J. 2010 Apr;44(2):107-12. (PMID: 19670036)
Microvasc Res. 2012 May;83(3):347-51. (PMID: 22349292)
Clin Hemorheol Microcirc. 2008;38(4):227-34. (PMID: 18334777)
Br J Haematol. 2003 Aug;122(4):645-50. (PMID: 12899720)
Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):359-60. (PMID: 13679676)
Am J Epidemiol. 2008 Nov 15;168(10):1153-60. (PMID: 18931370)
Eur J Clin Microbiol Infect Dis. 2010 Jul;29(7):845-9. (PMID: 20443041)
Eur J Pharmacol. 2008 Aug 20;590(1-3):170-6. (PMID: 18593582)
Arch Gerontol Geriatr. 2000 Aug 1;31(1):35-42. (PMID: 10989162)
Diabetes Care. 2006 Jul;29(7):1523-8. (PMID: 16801573)
Br J Haematol. 2004 Aug;126(3):385-91. (PMID: 15257711)
Clin Biochem. 2014 Apr;47(6):489-93. (PMID: 24503006)
Open Biol. 2012 Nov;2(11):120134. (PMID: 23226600)
Biorheology. 2000;37(4):301-12. (PMID: 11145076)
Adv Exp Med Biol. 2012;740:1017-38. (PMID: 22453982)
Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(6):53-6. (PMID: 12101897)
N Am J Med Sci. 2010 Apr;2(4):165-9. (PMID: 22624134)
Am J Cardiol. 2006 Jun 15;97(12):1745-8. (PMID: 16765126)
Chin J Nat Med. 2013 Nov;11(6):621-7. (PMID: 24345503)
Adv Colloid Interface Sci. 2014 Apr;206:414-27. (PMID: 24268588)
J Biomech. 2013 Nov 15;46(16):2802-8. (PMID: 24099744)
J Geriatr Cardiol. 2013 Sep;10(3):291-301. (PMID: 24133519)
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;Suppl 22:61-5. (PMID: 19425291)
Clin Chem. 2010 May;56(5):693-5. (PMID: 20348398)
Int J Immunopharmacol. 1993 Jul;15(5):641-6. (PMID: 8397168)
Eur Heart J. 2004 Jun;25(12):1049-56. (PMID: 15191776)
Int J Cardiol. 2009 May 15;134(2):189-94. (PMID: 18495262)
Clin Hemorheol Microcirc. 2010;44(2):75-85. (PMID: 20203362)
Eur J Clin Invest. 2005 Feb;35(2):93-8. (PMID: 15667579)
Stroke. 2003 Dec;34(12):2995-8. (PMID: 14605325)
Brain Res Bull. 2000 Oct;53(3):245-54. (PMID: 11113577)
Clin Hemorheol Microcirc. 2011;49(1-4):431-9. (PMID: 22214714)
J Neural Transm Park Dis Dement Sect. 1994;7(3):195-209. (PMID: 7710671)
Clin Chem Lab Med. 2010 Jun;48(6):805-13. (PMID: 20374041)
Pharmacopsychiatry. 1988 Aug;21 Suppl 1:26-32. (PMID: 2905813)
Clin Hemorheol Microcirc. 2009;43(3):223-32. (PMID: 19923692)
Transfus Med Hemother. 2012 Oct;39(5):302-7. (PMID: 23801920)
Br J Biomed Sci. 2010;67(2):67-70. (PMID: 20669761)
Biomech Model Mechanobiol. 2014 Apr;13(2):239-58. (PMID: 23670555)
Exp Cell Res. 2014 Feb 15;321(2):255-66. (PMID: 24211746)
Urol Res. 1996;24(3):129-34. (PMID: 8839479)
Br J Cancer. 2006 Jun 19;94(12):1823-32. (PMID: 16773076)

0 (Blood Proteins)
AK5Q5FZH2R (Pyrithioxin)
0 (Vinca Alkaloids)
543512OBTC (vinpocetine)

Date Created: 20141231 Date Completed: 20150821 Latest Revision: 20260506

20260506

PMC4274818

10.1155/2014/324307

25548768