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Protective effect of Morus alba leaves on haloperidol-induced orofacial dyskinesia and oxidative stress.

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  • المؤلفون: Nade VS;Nade VS; Kawale LA; Yadav AV
  • المصدر:
    Pharmaceutical biology [Pharm Biol] 2010 Jan; Vol. 48 (1), pp. 17-22.
  • نوع النشر :
    Comparative Study; Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE
    • بيانات النشر:
      Publication: [London] : Taylor & Francis
      Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998-
    • الموضوع:
      Morus* ; Plant Leaves*; Dyskinesia, Drug-Induced/*prevention & control ; Haloperidol/*toxicity ; Oxidative Stress/*drug effects ; Plant Extracts/*therapeutic use; Dyskinesia, Drug-Induced/metabolism ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/physiology ; Movement Disorders/metabolism ; Movement Disorders/prevention & control ; Oxidative Stress/physiology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Animals ; Male ; Rats ; Rats, Wistar
    • نبذة مختصرة :
      Long-term treatment with haloperidol, a typical neuroleptic, induces neurodegeneration caused by excitotoxicity and oxidative stress, which play an important role in the development of orofacial dyskinesia. In the present investigation, an attempt has been made to examine the effect of a concomitant treatment of methanol extract of Morus alba Linn. (Moraceae) leaves (100-300 mg/kg, i.p.) and haloperidol (1 mg/kg, i.p.) on an animal model of tardive dyskinesia. Rats were treated for 21 days with haloperidol and Morus alba extract; vacuous chewing movements and tongue protrusions were counted. The extract attenuated the increase in vacuous chewing movements and tongue protrusions induced by haloperidol, which were quantified on day 22. The extract showed a marked effect on behavioral parameters altered by haloperidol treatment. Similar treatment with extract attenuated haloperidol-induced lipid peroxidation and nitrite and normalized superoxide dismutase, catalase, and protein in comparison to the control group. The results suggest a protective effect of Morus alba extract against haloperidol-induced orofacial dyskinesia and oxidative stress.
    • الرقم المعرف:
      0 (Plant Extracts)
      J6292F8L3D (Haloperidol)
    • الموضوع:
      Date Created: 20100722 Date Completed: 20110425 Latest Revision: 20131121
    • الموضوع:
      20260130
    • الرقم المعرف:
      10.3109/13880200903029357
    • الرقم المعرف:
      20645751