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E. coli clinical isolates: Phylogrouping and virulence factors in Alexandria, Egypt.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • نبذة مختصرة :
      المقال يركز على تصنيف الأنواع وعوامل الضراوة لعزلات الإشريكية القولونية (E. coli) السريرية في الإسكندرية، مصر. قامت الدراسة بتحليل 50 عزلة سريرية من الإشريكية القولونية، وكشفت أن 62% منها كانت مقاومة متعددة الأدوية (MDR) و8% كانت مقاومة للأدوية بشكل واسع (XDR). كانت المجموعة التصنيفية B2 هي الأكثر انتشارًا، حيث شكلت 52% من العزلات، وكان الجين الأكثر شيوعًا للضراوة المكتشف هو papG (78%). تسلط النتائج الضوء على المقاومة الكبيرة للمضادات الحيوية والملفات المتنوعة للضراوة للإشريكية القولونية في المنطقة، مما قد يساعد في توجيه استراتيجيات التشخيص والعلاج المستقبلية للعدوى التي تسببها هذه المُمْرِضَة. [Extracted from the article]
    • نبذة مختصرة :
      Background: Escherichia coli (E. coli) can be categorized into many pathotypes which represent groups of strains with specific pathogenic characteristics. Aim: This study aimed to identify phylogroups and different virulence factors in E coli isolated from clinical specimens. Methods: Fifty clinical E. coli isolates were included in this study. Identification and antibiotic susceptibility testing were performed by Vitek® 2 compact system. Virulence genes detection and phylogroup gene alleles were performed using SYBR Green Real-time PCR. Results: The results revealed high antibiotic resistance; 62% of the isolates were multidrug resistant (MDR) and 8% were extensively drug resistant (XDR). The most prevalent virulence gene was papG (78%) while the least was hlyA (22%). Phylogroup B2 was the most predominant (52%), followed by (10%) group D, (8%) group C and group E each, (6%) group B1, (4%) clade1 and (2%) group F. Conclusion: Phylogroup B2 had all the virulence genes investigated in this study and it was more associated with sat and hlyA virulence genes. [ABSTRACT FROM AUTHOR]
    • نبذة مختصرة :
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