نبذة مختصرة : Simple Summary: Inflammatory fibroid polyps, also known as Vanek's tumors, are rare benign lesions of the gastrointestinal tract that can mimic malignant conditions, posing a diagnostic challenge. This study presents the largest multicentric analysis of these tumors to date, aiming to characterize their clinical presentation, anatomical distribution, and management strategies. We provide valuable insights into the effectiveness of endoscopic and surgical approaches, particularly in relation to tumor location and size. Our findings may contribute to optimizing diagnostic accuracy, guiding treatment decisions, and reducing unnecessary surgical interventions. Objectives: Inflammatory fibroid polyps, also known as Vanek's tumors, are rare benign lesions of the gastrointestinal tract. Although the exact cause remains unclear, several theories suggest an association with inflammatory processes and genetic factors. This study aims to present the largest cohort of inflammatory fibroid polyp cases to date, analyzing their clinical presentation, diagnostic methods, and treatment approaches. Materials and methods: A retrospective multicentric analysis was conducted on 67 patients diagnosed with inflammatory fibroid polyps between 2013 and 2023 across four hospitals. Clinical data regarding tumor location, size, symptoms, and treatment were collected. Non-parametric statistical tests, including the chi-square test, Cramér's V coefficient, and the Mann–Whitney U test, were used to identify association between tumor characteristics, location, and treatment outcomes. Results: The cohort included 67 patients (58.2% female, median age 60 years). The stomach was the most common tumor site (47.8%), followed by the colon (32.8%), and small intestine (10.4%). The majority of patients (73.1%) were asymptomatic, while 9% experienced intestinal obstruction, all of which were located in the small intestine. Endoscopic resection was successful in 77.6% of cases, but surgical intervention was more frequently required for tumors in the small intestine. A significant association was found between larger tumor size, emergency presentation, intestinal location, and the need for surgery. Conclusions: Inflammatory fibroid polyps are commonly managed with endoscopic resection, particularly in gastric and colonic locations. However, small intestinal tumors more often need surgical treatment, especially when presenting with complications like intestinal obstruction. [ABSTRACT FROM AUTHOR]
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