Assessment of Serum Interleukin-36γ Level in Patients with Acne Vulgaris and Post-Acne Scars.

المقال يركز على تقييم مستويات السيروم من إنترلوكين-36γ (IL-36γ) لدى المرضى الذين يعانون من حب الشباب العادي (AV) والندبات الناتجة عن حب الشباب. شملت الدراسة 45 مريضًا من AV و45 شخصًا سليمًا، وكشفت النتائج أن مرضى AV لديهم مستويات أعلى بشكل ملحوظ من IL-36γ في السيروم مقارنةً بالمجموعة الضابطة، مع وجود ارتباط إيجابي بين مستويات IL-36γ وشدة حب الشباب. بالإضافة إلى ذلك، لوحظت مستويات أعلى من IL-36γ لدى المرضى الذين لديهم تاريخ عائلي من AV وأولئك الذين يعانون من ندبات ما بعد حب الشباب. تشير النتائج إلى أن IL-36γ قد يلعب دورًا مهمًا في العمليات الالتهابية المرتبطة بـ AV وتطور الندبات الناتجة عن حب الشباب، مما يشير إلى إمكانيات علاجية محتملة. [Extracted from the article]

Background: Acne vulgaris (AV) is a typical inflammation-related condition of the pilosebaceous apparatus that has extremely detrimental impact on one's quality of life & mental health. Interleukin (IL)-36 cytokines (α, β, γ) promote the activation of T-helper 1 and T-helper-17 cells, which then secrete tumor necrosis factor-, interferon-γ, IL-17, IL-22 in addition to other inflammatory mediators. These cytokines stimulate epithelial cells for producing numerous growth factors and inflammatory mediators, thereby exacerbating the inflammation. IL-36 cytokines have been associated with various conditions that are inflammation-related. Aim: Its objective was to evaluate IL-36γ serum levels among AV participants and healthy controls, and to look into any possible connection among IL-36 & the severity of AV. Patients and methods: 45 participants were enrolled in this study after they presented with AV, along with 45 controls who did not have AV. Enzyme-linked immunosorbent assay (ELISA) was utilized to evaluate serum levels of IL-36γ in AV patients and controls. Results: The study revealed that cases with AV had significantly higher IL-36γ serum levels than controls (p < 0.001). IL-36γ serum levels correlated positively with AV severity (P=0.002). Cases with severe acne had higher levels than those with mild & moderate acne (p=0.005). Moreover, IL-36γ serum levels were significantly higher among cases with positive family history of AV (p=0.019). Conclusion: Individuals with AV had significantly greater serum IL-36γ levels in contrast to controls and they were related to AV severity and post acne scarring. IL-36γ may therefore show a significant function in AV inflammatory reactions and the induction of post acne scarring. [ABSTRACT FROM AUTHOR]

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