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Myocardial Na+ during ischemia and accumulation of Ca2+ after reperfusion: a study with monensin and dichlorobenzamil.

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Kawada T;Kawada T; Yoshida Y; Sakurai H; Imai S
  • المصدر:
    Japanese journal of pharmacology [Jpn J Pharmacol] 1992 Jun; Vol. 59 (2), pp. 191-200.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 2983305R Publication Model: Print Cited Medium: Print ISSN: 0021-5198 (Print) Linking ISSN: 00215198 NLM ISO Abbreviation: Jpn J Pharmacol Subsets: MEDLINE
    • بيانات النشر:
      Publication: -2002: Kyoto : Japanese Pharmacological Society
      Original Publication: Kyoto.
    • الموضوع:
      Calcium/*metabolism ; Myocardial Ischemia/*metabolism ; Myocardial Reperfusion Injury/*metabolism ; Sodium/*metabolism; Adenine Nucleotides/metabolism ; Amiloride/analogs & derivatives ; Amiloride/pharmacology ; Animals ; In Vitro Techniques ; Ion Transport/drug effects ; Male ; Monensin/pharmacology ; Myocardial Ischemia/physiopathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardium/metabolism ; Perfusion ; Potassium/metabolism ; Rats
    • نبذة مختصرة :
      The intracellular cation contents were determined in isolated perfused rat heart using cobaltic EDTA as a marker of the extracellular space. In hearts in which Na+ accumulation was induced with monensin, a Na+ ionophore, during 20 min-ischemia which otherwise did not result in accumulation of Na+, the levels of Na+ and Ca2+ were significantly higher after reperfusion with a significant decrease in K+. While the recovery of the cardiac mechanical function (CMF) was complete after reperfusion in control hearts, the recovery was incomplete in monensin-hearts. Dichlorobenzamil (DCB), the most specific inhibitor of Na(+)-Ca2+ exchanger, infused for 10 min before induction of ischemia in a dose of 10(-5) M, which produced a definite suppression of CMF (over 80%), inhibited the accumulation of Ca2+ and Na+ and the loss of K+ and ATP after 40 min-ischemia and reperfusion. The same dose of DCB given for 3 min before induction of ischemia and after reperfusion, which produced a less than 20% inhibition of CMF, failed to prevent the Ca2+ accumulation after 40 min-ischemia and reperfusion. These findings are at variance with the idea that the accumulation of Na+ during ischemia and the consequent augmented operation of Na(+)-Ca2+ exchange is responsible for accumulation of Ca2+ after reperfusion.
    • الرقم المعرف:
      0 (Adenine Nucleotides)
      1166-01-4 (3',4'-dichlorobenzamil)
      7DZO8EB0Z3 (Amiloride)
      906O0YJ6ZP (Monensin)
      9NEZ333N27 (Sodium)
      RWP5GA015D (Potassium)
      SY7Q814VUP (Calcium)
    • الموضوع:
      Date Created: 19920601 Date Completed: 19921204 Latest Revision: 20190725
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1254/jjp.59.191
    • الرقم المعرف:
      1434115