Parental determinants of metabolic syndrome among adolescent Asian Indians: A cross-sectional analysis of parent-offspring trios.

Background The aim of the present study was to investigate the relationship between parental metabolic syndrome ( MS) and the risk of MS and associated abnormalities in adolescent offspring. Methods This cross-sectional study was performed on 304 adolescents (12-16 years; 236 children with at least one parent and 124 father-mother-child trios) recruited from four schools representing different socioeconomic strata from Vellore, India. Anthropometric data was collected and blood pressure, blood glucose, and lipids were measured. Results The prevalence of MS in adolescent offspring, fathers, and mothers was 3.3%, 52.5%, and 48.7% respectively. The most commonly observed metabolic abnormality among adolescents was lower high-density lipoprotein. Maternal waist circumference ( WC) was strongly correlated with adolescent body mass index ( P = 0.007), WC ( P < 0.001), serum triglycerides ( P = 0.02), and systolic ( P = 0.005) and diastolic ( P = 0.01) blood pressure. Maternal MS status was significantly associated with a greater risk of central obesity ( WC odds ratio [ OR] 2.02; 95% confidence interval [ CI] 1.21-3.17) in offspring. Both parents having MS conferred a significant effect on the child's WC ( OR 1.21; 95% CI 1.72-2.07) and increased risk of MS ( OR 6.19; 95% CI 1.64-23.26). Conclusions This study highlights the possible heritable parental components that may contribute to the MS phenotype in offspring: MS in adolescent offspring is related to parental MS status, and maternal traits reflect offspring adiposity and metabolic traits more strongly than paternal factors. Therefore, adolescent children of parents with MS should be targets for primordial prevention of cardiometabolic disease. [ABSTRACT FROM AUTHOR]

摘要 背景 当前这项研究的目的是调查父母具有代谢综合征(metabolic syndrome,MS)或者MS危险因素与青春期子女伴随的异常代谢之间的关系。 方法 这项横断面研究是在304名青少年(12-16岁;其中236名儿童与至少1名父母都有MS,124名儿童与父母三者都有MS)中进行的,所招募的青少年来自4所代表了印度韦洛尔不同社会经济阶层的学校。收集人体测量学数据并且测量了血压、血糖以及血脂。 结果 青春期子女、父亲以及母亲的MS患病率分别为3.3%、52.5%与48.7%。在青少年中观察到的最常见的代谢异常是高密度脂蛋白水平较低。母亲的腰围与青少年的体重指数( P = 0.007)、WC( P < 0.001)、血清甘油三酯( P = 0.02)、收缩压( P = 0.005)以及舒张压( P = 0.01)之间都有强烈的相关性。母亲的MS状态与子女更高的向心性肥胖风险(WC优势比[OR]为2.02;95%可信区间[CI]为1.21-3.17)之间具有显著的相关性。双亲都有MS对儿童的腰围(OR为1.21;95% CI为1.72-2.07)和MS风险的增加(OR为6.19;95% CI为1.64-23.26)都有显著的影响。 结论 这项研究的亮点在于阐明了父母哪方面的遗传因素可能对子女的MS表型造成影响:青少年子女的MS与父母的MS状态有关,并且与父亲因素相比发现母亲的特征对子女的肥胖以及代谢特征的影响更为强烈。因此,父母合并MS的青少年儿童应该针对心血管代谢性疾病做出一级预防 [ABSTRACT FROM AUTHOR]

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