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A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

• Source: Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism

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Staphylococcus aureus mutants resistant to the feed-additive monensin show increased virulence and altered purine metabolism

• Authors : Warsi, Omar M.; Upterworth, Lina M.; Breidenstein, Annika

Subjects: drug resistance evolution; drug resistance mechanisms; ionophore

• Source: mBio. 15(2)

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HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma

• Authors : Pengyu Geng; Fei Ye; Peng Dou

Subjects: LUAD; EGFR; Purine metabolism

• Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)

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Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase.

• Authors : Stachelska-Wierzchowska, Alicja¹ (AUTHOR) ; Narczyk, Marta² (AUTHOR) ; Wierzchowski, Jacek¹ (AUTHOR)

Subjects: *XANTHINE oxidase; *ISOTHERMAL titration calorimetry; *APPLIED sciences

• Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10426. 26p.

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Utilizing an integrated bioinformatics and machine learning approach to uncover biomarkers linking ulcerative colitis to purine metabolism-related genes

• Authors : Tian Chen; Yiqiu Tao; Qingyuan Wang

Subjects: Ulcerative colitis; Purine metabolism genes; Lasso regression

• Source: Heliyon, Vol 10, Iss 21, Pp e38403- (2024)

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HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.

• Authors : Geng, Pengyu^1,2 (AUTHOR); Ye, Fei³ (AUTHOR); Dou, Peng^1,2 (AUTHOR)

• Source: Journal of Experimental & Clinical Cancer Research (17569966). 9/30/2024, Vol. 43 Issue 1, p1-14. 14p.

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Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in Cancer.

• Authors : Allegrini, Simone^1,2,3 (AUTHOR) ; Camici, Marcella¹ (AUTHOR) ; Garcia-Gil, Mercedes^2,3,4 (AUTHOR)

Subjects: *ENZYME metabolism; *CELL metabolism; *NUCLEOTIDE synthesis

• Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6735. 17p.

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Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis

• Authors : Keda Yang; Xiaochuan Wang; Chi Zhang

Subjects: Cytology; QH573-671

• Source: Cell Death and Disease, Vol 15, Iss 11, Pp 1-30 (2024)

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Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

• Authors : Yuting Huang; Szehoi Chan; Shuna Chen

Subjects: Colorectal cancer; Oxaliplatin resistance; Purine metabolism

• Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

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Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders

• Authors : Steen, NE; Dieset, I; Hope, S

Subjects: Medicin och hälsovetenskap

• Source: Psychological medicine. 50(4):595-606

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