نتائج البحث

Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics

• Authors : Yupiao Feng; Xinting Hu; Xin Wang

Subjects: Targeted protein degradation; Hematologic malignancies; Clinical trials

• Source: Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)

تفاصيل العنوان

Protein degradation is required for normal proliferation of Drosophila intestinal stem cells.

• Authors : Joel, Praise O.¹; Swanson, Christina I.¹

• Source: Bios. 2024, Vol. 95 Issue 3, p162-169. 8p.

تفاصيل العنوان

Expanding the horizons of targeted protein degradation: A non-small molecule perspective

• Authors : Xiaowei Huang; Fengbo Wu; Jing Ye

Subjects: Targeted protein degradation; Proteolysis targeting chimera; Endocytosis

• Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2402-2427 (2024)

تفاصيل العنوان

Vigeo Promotes Myotube Differentiation and Protects Dexamethasone-Induced Skeletal Muscle Atrophy via Regulating the Protein Degradation, AKT/mTOR, and AMPK/Sirt-1/PGC1α Signaling Pathway In Vitro and In Vivo.

• Authors : Cheon, Yoon-Hee¹ (AUTHOR) ; Lee, Chang-Hoon^1,2 (AUTHOR) ; Chung, Chong-Hyuk^1,2 (AUTHOR)

• Source: Nutrients. Aug2024, Vol. 16 Issue 16, p2687. 17p.

تفاصيل العنوان

A system for inducible mitochondria-specific protein degradation in vivo

• Authors : Sanyal, S; Kouznetsova, A; Strom, L

Subjects: Medicin och hälsovetenskap

• Source: Nature communications. 15(1):1454

تفاصيل العنوان

PA200-Mediated Proteasomal Protein Degradation and Regulation of Cellular Senescence.

• Authors : Wen, Pei¹ (AUTHOR) ; Sun, Yan¹ (AUTHOR) ; Jiang, Tian-Xia² (AUTHOR)

Subjects: *CELLULAR aging; *PROTEOLYSIS; *DNA repair

• Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5637. 14p.

تفاصيل العنوان

Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome.

• Authors : Poliquin, Sarah^1,2 (AUTHOR) ; Nwosu, Gerald^2,3,4 (AUTHOR) ; Randhave, Karishma⁴ (AUTHOR)

Subjects: *MUTANT proteins; *MOLECULAR chaperones; *FEBRILE seizures

• Source: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4601. 21p.

تفاصيل العنوان

Insomnia impairs muscle function via regulating protein degradation and muscle clock

• Authors : Ouyang, Hui; Jiang, Hong; Huang, Jin

Subjects: Quantitative Biology - Neurons and Cognition

تفاصيل العنوان

Chromophore-Assisted Light Inactivation for Protein Degradation and Its Application in Biomedicine.

• Authors : Zhou, Lvjia¹ (AUTHOR) ; Na, Jintong¹ (AUTHOR) ; Liu, Xiyu¹ (AUTHOR)

• Source: Bioengineering (Basel). Jul2024, Vol. 11 Issue 7, p651. 16p.

تفاصيل العنوان

Protein Degradation with New Chemical Modalities : Successful Strategies in Drug Discovery and Chemical Biology

• Authors : Hilmar Weinmann; Craig Crews

Subjects: Proteolysis; Drugs--DesignMEDICAL / Pharmacology; SCIENCE / Life Sciences / Biochemistry; SCIENCE / Chemistry / Organic

تفاصيل العنوان