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A set of 840 mouse oocyte genes with well-matched human homologues

• Authors : Stanton, J.L.; Green, D.P.L.

Subjects: Embryology

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Transcriptionally Active Xenopus laevis Somatic 5 S Ribosomal RNA Genes Are Packaged with Hyperacetylated Histone H4, Whereas Transcriptionally Silent Oocyte Genes Are Not

• Authors : Howe, LeAnn; Ranalli, Tammi A.; Allis, C. David

Subjects: Cell Biology; Molecular Biology; Biochemistry

• Source: Journal of Biological Chemistry ; volume 273, issue 33, page 20693-20696 ; ISSN 0021-9258

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Figure 1. nos-1nos-2 PGCs upregulate transcripts expressed in oocytes. ; (A) Mutual antagonism between DRM/LIN-15B transcription factor and PRC2/MES-4 chromatin modifiers balances activities that promote somatic (red) and germline (green) gene expression. In somatic lineages, LIN-15B and DRM transcription factors opposes PRC2 to silence germline genes (Petrella et al., 2011). In pregametic germ cells, PRC2 activates germline genes (with the help of MES-4) and silences somatic genes and X-linked genes, including genes expressed in oocytes (e.g. lin-15B) (Gaydos et al., 2012). In this study, we show that Nanos is required to remove maternally-inherited LIN-15B from PGCs to allow proper PRC2/MES-4 function. (B) Germline cycle in C. elegans. The zygote (stripped red and green) inherits from the oocyte maternal mRNAs that promote the development of somatic (red) and germline (green) cell fates during embryogenesis. P4 is the germline founder cell that gives rise to Z2 and Z3, the two primordial germ cells. Z2 and Z3 do not divide and remain mostly transcriptionally quiescent during embryogenesis. They resume division and transcription in the first larval stage (L1). (C–D). Transcriptome comparison between PGCs isolated from wild-type and nos-1(gv5)nos-2(RNAi) L1 larvae using SMART-seq libraries (Materials and methods, See Figure 1—figure supplement 1B–C for results with Truseq libraries). (C) Volcano plot showing log2 fold-change in transcript abundance for each gene. The number of genes that were significantly up or downregulated in nos-1(gv5)nos-2(RNAi) (designated as nos-1/2) PGCs are indicated. Dashed line marks the significance cutoff of q = 0.05 (Y axis) above which genes were counted as misexpressed. (D) Bar graphs showing expected and observed number of genes (Y axis) in different expression categories (X axis). Genes were assigned to a particular expression category based on their preferential expression patterns as determined in (Gaydos et al., 2012; Ortiz et al., 2014); Materials and methods and Supplementary file 1). The lists are non-overlapping and include 1694 pregamete genes, 1594 oocyte genes, 2042 sperm genes, and 2684 somatic genes. Oocyte genes include genes required for oogenesis and maternal genes required for embryogenesis. Because genes were categorized based on their preferential gene expression pattern, genes on one list may also be expressed in other tissues. See Supplementary file 1 for complete gene lists. Pregamete and oocyte genes are overrepresented among downregulated genes and oocyte genes are overrepresented among upregulated genes. Asterisks indicate significantly more genes than expected (hypergeometric test, p-value

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Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.

• Authors : Assou, Said; Boumela, Imène; Haouzi, Delphine ...

Subjects: oocyte genes; embryo genes; embryo stem cells

• Source: ISSN: 1355-4786.

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Metabolomic alternations of follicular fluid of obese women undergoing in-vitro fertilization treatment.

• Authors : Song, Jingyan^1,2; Xiang, Shan¹; Pang, Conghui²

• Source: Scientific Reports. 4/6/2020, Vol. 10 Issue 1, p1-12. 12p.

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Identification of germ cell-specific genes in mammalian meiotic prophase.

• Authors : Li, Yunfei¹; Ray, Debjit^1,2; Ye, Ping^1,3

• Source: BMC Bioinformatics. 2013, Vol. 14 Issue 1, p1-13. 13p. 1 Color Photograph, 1 Diagram, 4 Charts, 5 Graphs.

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CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins.

• Authors : Chao Yu¹ (AUTHOR); Yin-Li Zhang¹ (AUTHOR); Wei-Wei Pan¹ (AUTHOR)

• Source: Science. 12/20/2013, Vol. 342 Issue 6165, p1518-1521. 4p.

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Learning "graph-mer" Motifs that Predict Gene Expression Trajectories in Development.

• Authors : Xuejing Li¹; Panea, Casandra²; Wiggins, Chris H.³

• Source: PLoS Computational Biology. Apr2010, Vol. 6 Issue 4, p1-13. 13p. 4 Diagrams, 1 Chart, 3 Graphs.

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Search for the genes involved in oocyte maturation and early embryo development in the hen.

• Authors : Elis, Sebastien¹ ; Batellier, Florence¹ ; Couty, Isabelle¹

• Source: BMC Genomics. 2008, Vol. 9, Special section p1-20. 20p. 1 Black and White Photograph, 5 Diagrams, 4 Charts, 4 Graphs.

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Maternal age-related differential global expression profiles observed in human oocytes.

• Authors : Steuerwald, Nury M. ; Bermúdez, Mercedes G.; Wells, Dagan

• Source: Reproductive BioMedicine Online (Reproductive Healthcare Limited). Jun2007, Vol. 14 Issue 6, p700-708. 9p.

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